目的：观察Moria M2型90与110μm角膜刀制作角膜瓣在准分子激光角膜原位磨镶术（laser in situ keratomileusis，LASIK）的疗效和并发症，探讨Moria M2型90刀头在LASIK中应用的有效性、安全性和优点。 方法：选取通过术前检查并自愿行LASIK手术的患者105例202眼，按随机数字表分成两组，使用Moria M2型90刀头LASIK患者51例98眼，110刀头LASIK患者54例104眼做对照，术后即使用光学相干断层扫描仪（OCT）检测两组角膜瓣厚度，观察两组术后1d;1wk;1,3mo裸眼视力、矫正视力和角膜瓣形态、对合情况、并发症。 结果：90刀头组术后角膜瓣厚度为118.3±15.2μm，110刀头组术后角膜瓣厚度为130.5±17.1μm，有显著性差异。90刀头组均未发现层间点状金属碎屑，110刀头组有层间点状金属碎屑个例（12例），有显著性差异。两组角膜瓣形态、对合情况、术后反应、术后裸眼视力相当。 结论：应用90刀头LASIK的疗效及并发症和110刀头LASIK相当，但90刀头保留角膜基质床相对较厚，可矫治的屈光度更大，术后层间点状金属碎屑并发症更少，具有更好的安全性和更宽的适应范围。

AIM:To study the curative effect,complications, safety and merit of Knife 90 and 110 of Moria M2 in excimer laser in situ keratomileusis(LASIK) for myopia. METHODS:The selected 105 cases (202 eyes) of LASIK surgery patient were divided into two groups according to the stochastic tables. Knife 90 of Moria M2 was used in 51 cases (98 eyes) of LASIK patients, Knife 110 in 54 cases (104 eyes) of LASIK patients as control.After operation, optical coherence tomography (OCT) was used to detect two groups of corneal flap thickness.Two groups of techniques were observed 1 day, 1 week, 1 month, and 3 months postoperatively with uncorrected visual acuity (UCVA), corrected visual acuity(CVA) and corneal flap shape, involution situation, complications. RESULTS:Corneal flap thickness of Knife 90 group was 118.3±15.2μm, corneal flap thickness of Knife 110 group was 130.5±17.1μm, having significant difference. Knife 90 group had not discovered interlaminar punctiform metal detritus, Kinfe 110 group had interlaminar punctiform metal detritus case (12 cases), having significant difference.The two groups were similar in form of the corneal flap, involution situation, postoperative reaction and postoperative UCVA. CONCLUSION: The LASIK efficacy and complications of Knife 90 are similar with Kinfe 110, however, Knife 90 can retain a relative thicker cornea stroma, correct higher diopter, howe less interlaminar punctiform metal detritus and complications, therefore it has better safety and adaptation range．