目的：分析小儿先天性鼻泪管闭塞所致泪囊炎的病原菌及其药敏结果，指导临床合理用药。 方法：对先天性鼻泪管阻塞患儿98例110眼的泪囊分泌物进行病原菌分离培养及药物敏感试验。 结果：从94眼的分泌物中共分离出155株细菌，病原菌阳性率为85.5%。其中革兰氏阳性球菌65.8%，革兰氏阴性杆菌23.9%。分离出的所有菌株对左氧氟沙星的敏感率为94.2%。 结论：药敏试验表明绝大多数细菌对左氧氟沙星有较高的敏感性，对于小儿先天性鼻泪管闭塞所致泪囊炎可给予新喹诺酮类抗生素滴眼液治疗。

AIM:To analyze the pathogenic bacteria and drug sensitivity in cases of dacryocystitis secondary to congenital nasolacrimal duct obstruction（CNDO）. METHODS:Bacterial cultures and drug sensitivity tests were conducted for the lacrimal sac secretion from the 98 cases (110 eyes) with CNDO. RESULTS:Totally 155 bacterial strains were isolated from lacrimal sac secretion in 94 eyes, and the pathogenic bacteria positive rate was 85.5%. The bacteria positive rates of Gram positive cocci and Gram negative bacilli were 65.8% and 23.9%, respectively. 94.2% of all isolated strains were sensitive to levofloxacin. CONCLUSION: Drug sensitivity test showed that the vast majority of bacteria had high sensitivity to levofloxacin. New quinolone antibiotic eye drops are applicable to dacryocystitis secondary to CNDO.

国家自然科学基金资助项目（No.81000402）