目的：研究复方樟柳碱联合物理疗法治疗12~18岁弱视患者的疗效。 方法：将60眼12～18岁弱视患者分为两组，分别给予复方樟柳碱穴位注射联合物理疗法与单纯物理治疗，定期随访6mo。分析治疗前后视力和P-VEP的变化。 结果：联合治疗组有效率50.00%，物理治疗组有效率2333%，两组间差异具有统计学意义（P<0.05）。联合治疗组治疗后与治疗前的P-VEP对比，潜伏期缩短，振幅增加，差异有统计学意义（P<0.01）；物理治疗组治疗后与治疗前的P-VEP对比，潜伏期缩短，差异有统计学意义（P<0.05），振幅改变的差异无统计学意义（P>0.05）；治疗后两组间P-VEP对比，联合治疗组P-VEP的潜伏期较短，振幅较高，差异有统计学意义（P<0.05）。 结论：复方樟柳碱辅助治疗12~18岁弱视患者有较好的效果。

AIM:To investigate the treatment effect of compound Anisodine and physical therapy for the treatment of amblypia in over-age children. METHODS:Totally 60 eyes of amblyopic children aged from 12 to 18 were divided into two groups, one group used compound Anisodine and physical therapy (CAPT group), the other was treated with physical therapy only (PT Group) .All patients were regularly checked in the following half year. Visual acuity, pattern-visual evoked potential (P-VEP) before and after treatment were tested and analyzed. RESULTS:After treatment, the effective rate of CAPT group was 50.00% and the PT group was 23.33%, the difference between these two groups was significant on statistics（P<0．05）. The comparison of the P-VEP before and after treatment in CAPT group was significant on statistics（P<0．01）,the latency was reduced and the amplitude was increased. The latency comparison of the P-VEP before and after treatment in PT group was significant on statistics（P<0.05）,but amplitude was not （P >0．05）. Comparing two groups P-VEP after treatment, the CAPT group was significant on statistics（P <0．05）, the latency of the P-VEP was reduced and the amplitude was increased. CONCLUSION: It is a good and effective way for the amblyopia in older children to have additional compound Anisodine treatment.