目的：观察光动力疗法治疗黄斑中心凹下脉络膜新生血管性疾病后1wk的早期变化，并比较两种不同的光动力治疗方法在术后1wk有无差别。 方法：经诊断有黄斑中心凹下脉络膜新生血管者16例19眼，随机分为两组，13眼接受维替泊芬标准光动力疗法(维替泊芬剂量为6mg/m²体表面积，静脉推注的速度为3mL/min，药物开始注射15min后开始激光照射，波长689nm，光照密度为600mW/cm²，光照时间为83s，光能量为50J/cm²)；6眼接受快速推注低能量照射光动力疗法(维替泊芬剂量为6mg/m²体表面积，静脉推注的速度为6mL/min，药物开始注射15min后开始激光照射，保持光照强度为600mW/cm²，波长689nm，光照时间为42s，光剂量25 J/cm²)。在术前及术后1wk分别行最佳矫正视力（BCVA）、ETDRS视力、OCT及眼底检查，利用OCT自带软件分别测量层间厚度（Tf）、神经上皮厚度（Nf）、外层高反光带厚度（T）、视网膜下液（SF）等观测值。比较患者术前及术后1wk各个观察指标的变化，并比较两组间观察指标有无差别。 结果：不同参数光动力疗法术后1wk视力及OCT图像中Tf，Nf，T，SF等差别无统计学意义（P>0.05）。术后1wk，标准光动力疗法和快速推注低能量光动力疗法之间各指标的差异无统计学意义（P>0.05）。 结论：标准参数光动力疗法和快速推注低能量照射光动力疗法在术后1wk对视网膜结构的影响无差异，两种治疗方法之间疗效无差异。 "

AIM: To study the early changes of choriodal neovascularization(CNV) one week after photodynamic therapy(PDT). Compare the differences between standard PDT and fast infusion reduced light dose PDT. METHODS: Sixteen cases（19 eyes） with subfoval CNV suffered PDT with visudyne. Of the 19 eyes included, 13 eyes suffered standard PDT (6mg/m² visudyne, injection speed is 3mL/min, the interval time between the injection and exposure to the light is 15 minutes, the wave length of light is 689nm, fluency of the light is 600mW/cm², duration of the light is 83 seconds, dose of light is 50J/cm²), 6 eyes suffered fast infusion reduced light dose PDT (6mg/m² visudyne, injection speed is 6ml/min, the interval time between the injection and exposure to the light is 15 minutes, the wave length of light is 689nm, fluency of the light is 600mW/cm², duration of the light is 42 seconds, dose of light is 25J/cm²).The changes of best-corrected visual acuity (BCVA), letters of early treatment for diabetic retinopathy study (ETDRS). Optical coherence tomography(OCT) before and one week after PDT were compared. Using the software of OCT, the bilaminar foveal thickness (Tf), neuroretinal foveal thickness (Nf), outer high reflectivity band thickness (T) and subretinal fluid thickness (SF) were measured. Compare the changes of every observation indexes pre- and postoperatively as well as their differeces. RESULTS: No significant changes had found in OCT images or visual acuity one week after PDT(P>0.05). All the indexes had no significant differences after PDT or between the groups（P>0.05）. CONCLUSION: There were no changes before and one week after PDT.Compared to standard PDT, fast infusion reduced light dose PDT had no differences.