目的：比较不同角膜厚度下非接触眼压计与Schiotz眼压计测量结果的差异。 方法：对314例627眼分别用角膜测厚仪测量角膜厚度，非接触眼压计与Schiotz眼压计测量眼压，根据角膜厚度分为：较薄组（角膜厚度≤530μm）、正常组（530μm＜角膜厚度≤570μm）、较厚组（角膜厚度＞570μm）。采用配对t检验比较不同角膜厚度下两种测量结果的差异，并通过Bland-Altman进行一致性评价。 结果：角膜厚度较薄组170眼，正常组301眼，较厚组156眼。两种方法在较薄组、正常组、较厚组三组中的眼压值分别为12.82±2.67，12.84±2.37mmHg；13.67±2.66，1358±2.41mmHg；15.45±2.91，14.76±2.39mmHg。两种方法测量结果在角膜厚度正常和偏薄组中差异无统计学意义，偏厚组中差异有统计学意义。 结论：在角膜厚度≤570μm的人群中，眼压的检查可在非接触眼压计和Schiotz眼压计间选择一种检查；对于角膜厚度＞570μm的人群，需参考两种方法检查结果，进一步检查排除青光眼。

AIM:To compare the difference of intraocular pressure of non-contact tonometry and Schiotz tonometer in different corneal thickness. METHODS:Totally 314 cases (627 eyes) were recruited. Corneal thickness was measured by corneal pachymeter and intraocular pressure was measured by non-contact tonometry and Schiotz tonometer. Eyes were divided into 3 groups based on corneal thickness: thin group: corneal thickness＜530μm, normal group: 530μm＜corneal thickness ≤570μm and thick group: corneal thickness＞570μm. The statistical significance of differences was evaluated by paired t-test and the agreement was assessed by Bland-Altman analysis. RESULTS:The eyes of thin, normal and thick group were: 170, 301 and 156 eyes, respectively.The intraocular pressure of non-contact tonometry and Schiotz tonometer in 3 groups were 12.82±2.67 mmHg，12.84±2.37mmHg；1367±2.66mmHg，13.58±2.41mmHg；15.45±2.91mmHg，14.76±2.39mmHg, respectively. There was significant difference in thick group and no significant difference in other groups. CONCLUSION: It is suggested that either non-contact tonometry or Schiotz tonometer could measure intraocular pressure in eyes with corneal thickness≤570μm, and consult the intraocular pressure of the two measurements in eyes with corneal thickness ＞570μm.