目的：探讨配戴软性角膜接触镜(soft contact lens,SCL)对角膜中央厚度(central corneal thickness,CCT)、曲率的影响。方法：检测143例286眼配戴SCL患者的CCT、角膜地形图。154例308眼正常人为正常对照。比较连续配戴角膜接触镜不同年限患者和正常人的角膜厚度、角膜曲率的差异。结果：配戴SCL较短者(≤2a)的CCT与对照组相比并没有明显的变化；但戴镜时间超过2a的Ⅱ组和Ⅲ组与对照组及配戴SCL≤2a的Ⅰ组CCT相比时差异均有显著性(P<0.05)；配戴SCL对角膜曲率无显著影响。结论：短期配戴SCL后角膜厚度尚无明显的变化,但随着戴镜时间的延长,角膜厚度逐渐变薄。而不论长期或者较短时间配戴SCL角膜曲率并无显著变化,但随着戴镜时间的延长角膜的不规则性有增加的趋势。

AIM:To evaluate the influence of wearing soft contact lens(SCL) on central corneal thickness(CCT) and curvature.METHODS：The CCT and corneal topography of 143 cases (286 eyes) who were wearing SCL were measured with ultrasonic pachymeter. 154 normal subjects were selected as control. The difference of CCT and corneal curvature among normal subjects and subjects wearing SCL in different duration were analyzed.RESULTS：There was no statistically significant difference in CCT between short-term wearing patients(≤2 years) and the control. CCT of long-term wearing patients(>2 years) was significantly thinner than CCT of the control and the patients worn SCL short term(<2 years) (P<0.05). There was no significant difference among all groups in corneal curvature(P<0.05).CONCLUSION: CCT did not change in short term wearing eyes. However, CCT decreased gradually with time passing in long term of contact lens wear. There was no relation between corneal curvature and the time of contact lens wear. Corneal unregularity was inclined to increase with long-term wear of contact lenses.