目的:比较光学生物测量仪、Wavelight眼前节分析仪、Galilei眼前节分析仪、光学相干断层扫描仪(OCT)与A型超声角膜测厚仪对中央角膜厚度(central corneal thickness, CCT)测量的差别。方法:选取近视眼患者74例147眼,分别应用以上5种仪器做屈光术前检查,并将前4种仪器测量结果分别与A超测量做比较。结果:A型超声角膜测厚仪测量CCT平均为537.52±31.54μm,光学生物测量仪测量CCT平均为535.32±29.74μm,比A超小2.20 ±7.29μm（t=3.67,P<0.01）；Wavelight测量CCT平均为542.51±30.21μm,比A超大4.99 ±10.45μm（t=-5.79,P<0.01）；Galilei测量CCT平均为546.48±27.38μm,比A超大8.95±10.44μm（t=-10.40,P<0.01）；OCT测量CCT平均为530.33±28.61μm。比A超小7.20± 7.69μm（t=11.35,P<0.01）。4种仪器与A超测量结果差异有显著性。结论:在角膜厚度测量上,4种仪器与A超测厚结果存在差异,不能相互替代,可以作为参考。

AIM:To compare the differences of central corneal thickness (CCT) measured by optical bio-measurement, Wavelight anterior segment analyzer, Galilei anterior segment analyzer, optical coherence tomography (OCT) and A-mode ultrasonic pachymeter(USP).METHODS:All 74 cases (147 eyes) with myopia were examined before refractive surgery with more than five kinds of instruments respectively, the results were compared with USP. RESULTS:CCT measured by USP was 537.52±3154μm, 535.32±29.74μm by the optical bio-measurement, which was 2.20±7.29μm less than USP（t=3.67,P<0.01）. CCT was 542.51±30.21μm by Wavelight, which was 4.99±10.45μm more than USP（t=-5.79,P<0.01）. CCT was 546.48±27.38μm by Galile, which was 895±10.44μm more than USP（t=-10.40,P<0.01）. CCT was 530.33±28.61μm by OCT, which was 7.20± 7.69μm less than USP（t=11.35,P<0.01）. There were significantly statistical differences between these four methods and USP.CONCLUSION:On CCT measurement, there is difference between 4 types of instruments and A scan measurement outcome. They can not instead each other, but as raference.