方法：我院2011-01/2012-01治疗单疱病毒性角膜基质炎患者91例91眼，随机分为两组，A组应用10g/L环孢霉素A滴眼液和更昔洛韦凝胶，B组应用5g/L氯替泼诺滴眼液和更昔洛韦凝胶，其余均为对症治疗，随诊观察6～12(平均10)mo。

结果：两组治疗单疱病毒性角膜基质炎疗效无显著性差异，但A组治愈时间平均5.1±2.4d，B组治愈时间平均6.2±2.8d，A组较B组平均治愈时间短。两组治愈率及复发率无统计学差异。

结论：对于单疱病毒性角膜基质炎患者应用10g/L环孢霉素A滴眼液能够安全有效治愈，且治愈时间短。

METHODS: From January 2011 to January 2012, 91 cases 91 eyes with herpes simplex virus keratitis patients in our hospital were randomly divided into two groups: group A received 10g/L cyclosporin A eye drops and ganciclovir gel; group B was used 5g/L loteprednol etabonate ophthalmic solution and ganciclovir gel. The rest were symptomatic treatment. Two groups were followed up for 6-12 months, with an average of 10 months.

RESULTS: There was no significant difference in treatment effect of viral keratitis between two groups. But the average cure time in group A was 5.1±2.4 days, and that of group B was 6.2±2.8 days, indicating that the average cure time in group A was shorter than group B. The two group cure rate and recurrence rate had no statistical difference(P > 0.05).

CONCLUSION For herpes simplex virus keratitis patients, using 10g/L cyclosporin A eye drops can be safe and effective, but the cure time is long.