[关键词]
[摘要]
目的：通过荟萃分析评价我国人群白内障与高血压的相关关系。
方法：应用PubMed，Web of Knowledge，万方和CNIK数据库对以中英文全文发表的研究进行检索，将入选研究的数据整合，进行随机效应模型的荟萃分析，并按纬度、样本量进行亚组分析和敏感性分析。
结果：208个备选研究中，包含3 247例白内障患者的7个研究最终入选。随机效应模型合并比值比(OR值)为1.20(95% CI，1.01～1.38)，说明我国人群白内障的患病风险与高血压有关。且纬度和样本量的亚组分析结果显示，纬度是研究间变异来源。敏感性分析表明合并OR值保持稳定。
结论：荟萃分析结果提示高血压能提高我国人群白内障的患病风险。
[Key word]
[Abstract]
AIM: To comprehensively analyze the relationship between cataract and hypertension among Chinese population.
METHODS: An electronic search was performed inPubMed, Web of Knowledge, Wanfang data and CNKI. Afterwards we carried out a random-effect meta-analysis, followed by subgroup analysis on latitude and sample size, along with sensitivity analysis.
RESULTS: Totally 7 studies including 3247 cataract patients were eligible among 208 papers screened in our search. The odds ratio(OR)was 1.20(95%CI, 1.01-1.38). Subgroup analysis indicated latitude was covariate that led to heterogeneous. Sensitivity analysis confirmed our results' stability.
CONCLUSION: The meta-analysis results prompted hypertension can increase the risk of cataract of the Chinese population.
[中图分类号]
[基金项目]
国家自然科学基金项目(面上项目)(No.81273034)
