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[摘要]
信号转导与转录激活因子(signal transducer and activator of transcription，STAT)3是信号转导与转录激活因子家族成员之一，STAT3具有调节细胞生长、分化、增殖、凋亡、血管生成等生物学活性。STAT3广泛存在于包括视网膜等组织中，参与缺血性视网膜病变、糖尿病视网膜病变等多种视网膜疾病的发病。我们就STAT3生物学功能及在视网膜疾病中的作用做一综述。
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[Abstract]
Signal transducer and activator of transcription(STAT)3 is a member of the cytoplasmic transcription factors family which participates in a wide variety of physiological processes including cell growth, differentiation, proliferation, apoptosis and angiogenesis. It broadly exists in various tissues as well as retina. The expression of STAT3 plays an important role in various retinal diseases including ischemic retinopathy, diabetic retinopathy. The purpose of this paper is to review the biological functions of STAT3, and its role in various.
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