Induced pluripotent stem cells(iPSCs)are reprogrammed through transduction of exogenous transcription factors, into somatic cells, reprogramming the somatic cells to embryonic stem cells-like cells with potencies of unlimited proliferation and pluripotent differentiation. This technology is a milestone in the field of regenerative medicine, and many related studies have been made these years. In the development of iPSCs technology, we have achieved a lot of progress; these will lay a foundation of cell therapy. Meanwhile, the successfully reprogrammed human somatic stem cells and good results in the study of animal models have been achieved. This article aims to emphasize the development of iPSCs in Ophthalmology.