[关键词]
[摘要]
目的:探讨糖尿病患者白内障超声乳化术后早期视力低下的影响因素。
方法:回顾性分析2008/2011年在我院行糖尿病性白内障超声乳化吸除术联合人工晶状体植入术600例600眼,以术后最佳矫正视力低于0.3为低视力标准,根据眼底糖尿病视网膜病变( diabetic retinopathy, DR)程度按照2002年国际临床分类法分为: A组(无明显视网膜病变)237眼, B组(非增生期糖尿病性视网膜病变,non-proliferative diabetic retinopathy, NPDR)363眼,其中B组分为:轻度NPDR 177眼,中度NPDR 150眼,重度NPDR 36眼。回顾性分析其导致低视力发生的影响因素。
结果:术后7d最佳矫正视力<0.3者, A组41眼(17.3%),B组103眼(28.4%),两组比较差异有统计学意义(P<0.05)。按流行病学方法对影响术后早期视力的5项因素进行分析, 引入多因素Logistic回归分析,得出5项因素的结果,晶状体核硬度(OR=4.065, 95% CI:2.289~7.312); 糖化血红蛋白(HbA1c)(OR=3.781,95% CI:2.256~6.439); DR分期(OR=3.987,95% CI:2.678~6.894); 术后角膜水肿(OR=1.089,95% CI:1.017~1.072); 年龄(OR=1.687,95% CI:1.171~2.416),然后分别对晶状体核硬度、HbA1c、DR分期、术后角膜水肿这4种低视力因素进行方差分析,P<0.05差异具有统计学意义。
结论:晶状体核硬度、HbA1c、DR分期、术后角膜水肿是糖尿病性白内障术后早期低视力的影响因素。
[Key word]
[Abstract]
AIM: To study the influence factors of early low vision in diabetics after phacoemulsification.
METHODS:Totally 600 eyes which were performed diabetic cataract phacoemulsification combined artificial lens implantation from 2008 to 2011 in our hospital were involved into retrospective analysis, with the best-corrected visual acuity less than 0.3 as the standard. According to the 2002 international clinical classification of diabetic retinopathy(DR), subjects were divided into: group A with 237 eyes(no retinopathy), group B( non-proliferative phase of diabetic retinopathy, NPDR)363 eyes, group B was divided into: the mild NPDR 177 eyes, moderate NPDR 150 eyes, severe NPDR 36 eyes. The related cause factors of low vision were analyzed retrospectively.
RESULTS:Seven days after the surgery, the best-corrected visual acuity <0.3 were in 41 eyes(17.3%)of group A; 103 eyes(28.4%)of group B. There was no statistical significance between 2 groups(P<0.05). According to epidemiological methods, 5 factors which affected the early postoperative visual were analyzed. Multi-factor logistic regression analysis was used. The results of the 5 factors were given out as following, crystal nucleus hardness(OR=4.065,95% CI: 2.289-7.312); HbA1c(OR=3.781,95% CI:2.256-6.439); DR stage(OR=3.987,95% CI: 2.678-6.894); postoperative corneal edema(OR=1.089, 95% CI:1.017-1.072); age(OR=1.687, 95% CI:1.171-2.416). Then the 4 factors of low vision including crystal nucleus hardness, HbA1c, DR stage and postoperative corneal edema were analyzed using analysis of variance(ANOVA)(P<0.05), and the differences were statistically significant.
CONCLUSION: Crystal nuclear hardness,glycosylated hemoglobin, DR stage, the corneal edema are the influencing factors of early postoperative low vision of diabetic cataract.
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[基金项目]
中国辽宁省自然科学基金资助项目(No.201102130)