方法：回顾性分析我院眼化学伤持续性角膜上皮缺损41例41眼，采用100%自体血清滴眼治疗，观察其疗效。

结果：酸性眼化学伤较碱性眼化学伤疗效好，两者差异有统计学意义(χ²=4.120，P=0.042)； 角膜上皮小面积缺损较大面积缺损疗效好，两者间差异有统计学意义(χ²=5.857，P=0.016)； 结膜及角膜缘小范围缺血较大范围缺血疗效好，两组间差异有统计学意义(χ²=4.137，P=0.042)。7例无效患者行结膜瓣遮盖术2例，行羊膜移植术5例。

结论：100%自体血清治疗眼化学伤持续性角膜上皮缺损安全、有效，可促进角膜上皮缺损修复，减少并发症，有很好的临床应用前景。

METHODS: Totally 41 cases(41 eyes)of persistent corneal epithelial defects of ocular chemical injury in our hospital treated with 100% autologous serum were identified and reviewed. The curative effect after the use of 100% autologous serum tear in persistent corneal epithelial defects of ocular chemical injury patients was observed.

RESULTS: The curative effect of acidic ocular chemical injury was better than alkaline ocular chemical injury, with significant difference(χ²=4.120, P=0.042); The curative effect of corneal epithelial defects of small area was better than corneal epithelial defects of large area, with significant difference(χ²=5.857, P=0.016); The curative effect of small range ischemia of conjuntiva and limbus cornea was better than wide range ischemia, with significant difference(χ²=4.137, P=0.042). In 7 invalid cases, 2 cases had undergone conjunctival flap masking operation, 5 cases had undergone amniotic membrane transplantation.

CONCLUSION: The use of 100% autologous serum in persistent corneal epithelial defects of ocular chemical injury is safe and effective. It could accelerate the repair of corneal epithelial defects, reduce complications. It would have a good prospect of clinical application.