Pupil examination is one of the important eye detection indicators, with the advantages of objective, noninvasive, repeatable. Many eye diseases demonstrate the relative afferent pupillary defect(RAPD)during the initial stage. Recently with the development of science and technology, the detection of RAPD is gradually realized to be quantitative and precise, other more, the operation is becoming more convenient. This may provide a more reliable objective index for diagnosis and prognosis of many blinding eye diseases. This review summarizes the articles about RAPD of blinding eye diseases in recent years.