方法：选取双眼行PRK术患者60例，术前及术后常规局部使用抗菌素、激素。根据局部使用非甾体抗炎药随机分组，溴芬酸钠滴眼液组30例60眼，术前3d开始点用溴芬酸钠滴眼液2次/d，至术后5d； 对照组30例60眼，术前3d开始点用普拉洛芬滴眼液4次/d，至术后5d。采用5级疼痛评估法，即无痛0度，轻痛1度，中度痛2度，重度痛3度，严重痛4度。记录术后3d内最高疼痛数值。

结果：疼痛调查表回收率100%。溴芬酸钠组0度20例(66.66%)，1度10例(33.33%)； 对照组0度10例(33.33%)，1度10例(33.33%)，2度7例(23.33%)，3度3例(10.00%)。统计学结果显示溴芬酸钠组与对照组之间有统计学差异(P<0.05)。

结论：溴芬酸钠滴眼液用于PRK术后止痛效果优于普拉洛克滴眼液，并且副作用小，依从性好。

METHODS: In a prospective randomized clinical trial, 60 patients underwent PRK. In addition to a standard regimen of topical antibiotics and topical steroids, 30 patients(the trial group)were treated withbromfenac ophthalmic solution twice daily from 3 days before surgery through 5 days after surgery. The other 30 patients(the control group)were treated with profenac ophthalmic solution four times daily from 3 days before surgery through 5 days after surgery. Patients completed a maximum pain assessment survey during the 5 days after surgery using the following 0-4 pain scale: 0=no pain, 1=mild pain, 2=moderate pain, 3=severe pain, 4=severe pain requiring immediate treatment.

RESULTS: The Mann-Whitney test showed a statistically significant difference between the bromfenac group and the control group in maximum pain score(P<0.05). However, all patients reported a pain assessment score below 2, with the exception of 3 patients in the control group who reported a score of 3.

CONCLUSION:Bromfenac ophthalmic solution is a reasonable analgesia for postoperative pain after PRK.