首页 > 过刊浏览>2013年第13卷第5期 >2013,13(5):918-920. DOI:10.3980/j.issn.1672-5123.2013.05.22
上一篇 | 下一篇

小儿弱视视觉皮层的BOLD-fMRI研究进展

Study of visual cortex of children amblyopia with blood oxygen level dependent-functional magnetic resonance imaging

发布日期：2013-05-06
  • 摘要
  • 访问统计
  • PDF预览
  • 参考文献
  • 相似文献
    [关键词]
    [摘要]

    血氧饱和度水平依赖性功能性核磁共振(BOLD- fMRI)利用血液中脱氧血红蛋白这一内源性顺磁物质作为对比剂，获得大脑皮层血管内MRI信号变化，从而得到大脑激活区域的图像，由于其定位精确、直观，属无创性检查，应用领域广泛，为弱视神经发生机制、眼优势柱、视觉运动觉及色觉等方面的研究提供了可视和客观的依据。

    [Key word]
    [Abstract]
    Blood oxygen level dependence-functional magnetic resonance imaging(BOLD-fMRI)utilizing the endogenous paramagnetic material-deoxygenated hemoglobin as a contrast agent gains signal changes of MRI in cortical intravascular and obtains images of the active area. Due to accurate location, intuitive and noninvasive, BOLD-fMRI is applied widely and provides objective evidence for amblyopia neurogenesis mechanism, ocular dominance column, motion perception and color vision.
    1 Conner IP, Odom JV, Schwartz TL, et al. Monocular activation of V1 and V2 ambyopic adults measured with fMRI. J AAPOS 2007; 11(4):341-350
    2 Wang X,Cui D,Zheng L,et al. Combination of blood oxygen level-dependent functional magnetic resonance imaging and visual evoked potential recordings for abnormal visual cortex in two types of amblyopia. Mol Vis 2012; 8:909-919
    3 Wallace DK. Stereoacuity in children with anisometropic amblyopia. J AAPOS 2011; 15(5):455-461
    4 Hussain Z.Perceptual Learning Reduces Crowding in Amblyopia and in the Normal Periphery.J Neurosci 2012; 32(2):474-480
    5 Holmes JM. Effect of age on response to amplyopia treatment in children. Arch Ophthalmol 2011; 129(11):1451-1457
    6 Bois C, Binot MC. Early visual screening appears essential to detect complete amplyopa risk and to treat strabismus earlier.J Fr Ophthalmol 2009; 32(9):629-639
    7 Pineles SL. Bilateral abnormalities of Optic Nerve Size and Eye Shape in Unilateral Amblyopia. Am J Ophthalmol 2009; 148(4):551-557
    8 Hess RF, Thompson B, Gole G, et al. Deficient responses from the lateral geniculate nucleus in humans with amblyopia. Eur J Neurosci 2009; 29(5):1064-1070
    9 AL-Haddad CE, EIMollayess GM, Mahfoud ZR, et al. Macular ultrastructural features in amblyopia using high-definition optical coherence tomography. Br J Ophthalmol 2013; 97(3):318-322
    10 Brown B, Feigl B, Gole GA, et al. Assessment of neuroretinal function in a group of functional amblyopea with documented LGN deficits. Ophthalmic Physiol Opt 2013; 33(2):138-149
    11 Li C,Cheng L, Yu Q, et al. Relationship of Visual Cortex Function and Visual Acuity in Anisometropic Amblyopic Children. Int J Med Sci 2012; 9(1):115-120
    12朱娟,燕振国,张文文. 屈光不正性弱视儿童皮层功能与弱视程度关系的功能磁共振研究.中国斜视与小儿眼科杂志2011; 19(1): 1-5
    13谢兵,王健,李传明,等. 儿童屈光参差性弱视的fMRI研究.中国放射学杂志 2006; 25(11):1055-1058
    14 Shaw P, Eckstrand K, Sharp W, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Nati Acad Sci USA 2007; 104(49):19649-19654
    15谢晟,江界峰,叶锦棠,等. 弱视儿童的MRI全脑皮层厚度分析.中国医学影像技术2009; 25(4):588-590
    16 Choi MY,Lee KM,Hwang JM,et al. Comparison between anisometropic and strabismic amblyopia using functional magnetic resonance imaging. Br J Ophthalmol 2001; 85:1052-1056
    17贾传海,卢光明, 张志强,等. 屈光参差性与斜视性弱视皮层损害的功能磁共振视网膜脑图对比研究.中华医学杂志2010; 90(21):1446-1452
    18宋修峰.健康人视觉刺激的fMRI研究.放射学实践2010; 25(9):986-989
    19王志,陈敏,周诚.视觉皮层对视觉刺激反应的研究—脑功能磁共振成像及磁共振波普的联合应用.中国医学影像技术2006; 22(1):19-21
    20梁平,丁新生,张志强,等. 视觉皮层功能检测中旋转光栅作为刺激方式的临床研究.国际眼科杂志2007; 7(5):1423-1424
    21 Secen J. Neural correlates of the multiple-object tracking deficit in amblyopia.Vision Res 2011; 51(23-24):2517-2527
    22卢光明,张志强,梁平,等. 弱视视觉运动功能的功能磁共振研究.中华放射学杂志2006; 40(5):494-497
    23王岩,马林,贾富仓,等. 人类颜色和运动知觉的事件相关功能磁共振成像.中国医学影像学杂志2003; 11(1):47-50
    24王俊,卢环.不同颜色光刺激视皮层脑功能成像研究.中国临床医学影像杂志2010; 21(8):536-539
    25王敏君.人脑视皮层定位、定量脑功能成像研究.中枢神经放射学2007; 26(6):543-547
    26 Hess RF. The amblyopic deficit and its relationship to geniculo-cortical processing streams.J Neurophysiol 2010; 104(1):475-483
您是第 9002995 位访问者
主管单位：陕西省卫生健康委员会
主办单位：中华医学会西安分会
地址：陕西省西安市碑林区雁塔路北段8号万达广场2栋1单元11707室
传真：029-82245172 电话：029-85205906/82245172
Email：ijo.2000@163.com,ijo2000@126.com
国际眼科杂志 ® 2025 版权所有   CC BY-NC-ND 4.0 适用于所有开放获取内容