方法：采用MTT比色法研究相同浓度Avastin与Lucentis 对HUVEC增殖作用的差异； Transwell小室检测相同浓度Avastin与Lucentis对HUVEC迁移作用的差异。

结果：MTT比色法显示，各浓度Avastin组、Lucentis组与对照组相比，吸光度值具有统计学差异(P<0.05)，相同浓度Avastin组与Lucentis组吸光度值无统计学差异(P>0.05)； Transwell分析方法显示，各浓度Avastin组、Lucentis组与对照组相比，HUVEC迁移率具有统计学差异(P<0.05)，相同浓度Avastin组与Lucentis组HUVEC细胞迁移率无统计学差异(P>0.05)。

结论：Avastin与Lucentis均可以抑制HUVEC增殖和迁移； 随着药物浓度增加，对HUVEC增殖和迁移的抑制作用增强； 相同浓度Avastin与Lucentis在体外实验中对HUVEC增殖和迁移的抑制作用无统计学差异(P>0.05)。

METHODS: MTT was used to assay the different effects on proliferation of HUVEC between the same concentration of Avastin and Lucentis; Transwell was used to measure the different effects on inhibition of HUVEC between the same concentration of Avastin and Lucentis.

RESULTS: MTT showed that A value was significantly different in the respective concentration Avastin groups, Lucentis groups and control group(P<0.05), and there was no significant difference between the same concentration Avastin groups and the Lucentis groups. Transwell analysis showed that the rate of HUVEC migration was significantly different in the respective concentration Avastin groups, Lucentis groups and control group(P<0.05), and there was no significant difference between the same concentration Avastin groups and the Lucentis groups.

CONCLUSION: Avastin and Lucentis could inhibit HUVEC proliferation and migration and inhibition effects of Avastin and Lucentis on HUVEC proliferation and migration enhancement enhangced with the increasing of the drug concentration. There was no significant difference in inhibition effects on proliferation and migration of HUVEC between the same concentration of Avastin and Lucentis in vitro.