方法：应用PCR-RFLP方法检测91例2型糖尿病患者和30例对照者的VEGF I/D基因和VEGF水平。

结果：NPDR组和PDR组DD基因型频率显著高于NDR组和对照组(P<0.01)； NPDR组和PDR组血清VEGF水平显著高于NDR组和对照组(P<0.01)。

结论：VEGF I/D基因多态性很可能与DR的发生发展有关，D等位基因可能是DR的易感基因。

METHODS: The 91 patients with diabetes and 30 control cases which VEGF I/D genotypes and VEGF level were determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).

RESULTS: The DD genotype frequencies were significantly higher in NPDR and PDR groups than in groups of NDR and control(P<0.01); The VEGF level were significantly higher in NPDR and PDR groups than in groups of NDR and normal control(P<0.01).

CONCLUSION: VEGF I/D gene polymorphism is associated with the development of diabetic retinopathy; D allele is probably a susceptible gene of diabetic retinopathy.