[关键词]
[摘要]
目的：探讨血管内皮生长因子(vascular endothelial growth factor，VEGF)I/D基因多态性与糖尿病视网膜病变(diabetic retinopathy，DR)的关系。
方法：应用PCR-RFLP方法检测91例2型糖尿病患者和30例对照者的VEGF I/D基因和VEGF水平。
结果：NPDR组和PDR组DD基因型频率显著高于NDR组和对照组(P<0.01)； NPDR组和PDR组血清VEGF水平显著高于NDR组和对照组(P<0.01)。
结论：VEGF I/D基因多态性很可能与DR的发生发展有关，D等位基因可能是DR的易感基因。
[Key word]
[Abstract]
AIM:To investigate the correlation of vascular endothelial factor(VEGF)I/D gene polymorphism with diabetic retinopathy(DR)in type 2 diabetes mellitus.
METHODS: The 91 patients with diabetes and 30 control cases which VEGF I/D genotypes and VEGF level were determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).
RESULTS: The DD genotype frequencies were significantly higher in NPDR and PDR groups than in groups of NDR and control(P<0.01); The VEGF level were significantly higher in NPDR and PDR groups than in groups of NDR and normal control(P<0.01).
CONCLUSION: VEGF I/D gene polymorphism is associated with the development of diabetic retinopathy; D allele is probably a susceptible gene of diabetic retinopathy.
[中图分类号]
[基金项目]
广州市荔湾区科技计划项目(No.20111213068)
