目的：探讨对大泡性角膜病变、翼状胬肉术后以及丝状角膜病变患者，通过配戴亲水性软性角膜接触镜，观察其在改善角膜刺激症状和促进角膜修复方面的治疗效果。

方法：将79例90眼入选住院患者采用临床对照法，随机分为治疗组和对照组，对照组按常规给予治疗、用药和局部包眼； 治疗组在按常规给予治疗、用药的同时加戴软性角膜接触镜。观察比较两组患者角膜刺激缓解症状和角膜愈合的情况。

结果：治疗组患眼角膜刺激症状较对照组有明显改善，两组差异具有统计学意义(H=26.801，P<0.001)，可以认为治疗组和对照组症状缓解情况的总体分布不同； 在促使角膜上皮愈合方面：术后1d总体治疗组和对照组角膜创面愈合情况比较，两组差异具有统计学意义(H=7.347，P<0.05)，可以认为术后1d总体治疗组和对照组角膜创面愈合情况的总体分布不同，其中翼状胬肉术后1d治疗组和对照组角膜创面愈合情况比较，差异具有统计学意义(H=13.495，P<0.001)，而大泡性角膜病变术后1d治疗组和对照组角膜创面愈合情况比较，差异无统计学意义(H=0.006，P>0.05)，同样丝状角膜炎术后1d治疗组和对照组角膜创面愈合情况比较，两组差异无统计学意义(H=0.245，P>0.05)； 术后1wk总体治疗组和对照组角膜创面愈合情况比较，差异无统计学意义(H=0.708，P>0.05)，尚不能认为术后1wk总体治疗组和对照组角膜创面愈合情况总体分布不同。

结论：合理使用治疗性角膜接触镜可减轻上述角膜疾病患者的痛苦，能有效的促进角膜的修复，缩短愈合时间，减轻了患者的经济负担，给临床治疗和护理带来方便等优点，但对于大泡性角膜病变，目前主要根治方法仍是穿透性角膜移植。

AIM: To investigate patients who suffering bullous keratopathy, postoperative pterygium and filamentary keratopathy, by wearing hydrophilic soft corneal contact lens at the same time, and observe the treatment effect on alleviating corneal irritation symptoms and promoting corneal repair.

METHODS: Totally 79 hospitalized patients(90 eyes)were divided into treatment group and control group randomly. The control group was given routine treatment; the treatment group had routine treatment and still wore hydrophilic soft corneal contact lens. The alleviating corneal irritation symptoms and promoting corneal repair between two groups were compared.

RESULTS: Cornea irritation symptoms in the treatment group patients had significantly alleviated than control group, there were significant differences(H=26.801,P<0.001), it can be considered that the overall distribution of the symptoms was different between the two groups. In corneal wound healing, there were significant differences(H=7.347, P<0.05)between the two groups at one day post-operation. It can be considered that the overall distribution of the symptoms was different between the two groups at 1 day post-operation. There were significant differences(H=13.495, P<0.001)between the two groups in pterygium post-operation. There were no significant differences(H=0.006, P>0.05)between the two groups in bullous keratopathy postoperation. There were no significant differences(H=0.245, P>0.05)between the two groups in filamentous keratitis post-operation. In corneal wound healing, there were not significant differences(H=0.708, P>0.05)between the two groups at one week post-operation. It cannot be considered that the overall distribution of the symptoms was different between the two groups.

CONCLUSION: The using of therapeutic corneal contact lens not only reduces the suffering of patients with corneal diseases, but also shortens the repairing time of corneal epithelial, reduces the economic pressure of the patients, and is conducive to clinical treatment and nursing. However, for bullous keratopathy, the main cure is still penetrating corneal transplantation at present.