[关键词]
[摘要]
水通道蛋白(aquaporins，AQPs)主要介导自由水沿渗透压梯度的被动跨生物膜转运，对水有高度选择性。晶状体只有两种水通道蛋白，晶状体上皮细胞表达的AQP1和晶状体纤维细胞表达的AQP0，它们共同调节晶状体水代谢，维持晶状体生理功能及透明性，其异常表达可导致白内障的发生。术文综述了近年来对水通道蛋白0，1的研究，并讨论水通道蛋白与白内障发生的关系。
[Key word]
[Abstract]
Water channel protein(aquaporins, AQPs)mainly mediates the passive transport of free water along the osmotic pressure gradient to across biological membrane. It is highly selective for water. There are only two kinds of water channel protein in lens, lens epithelial cells express AQP1, lens fiber cells express AQP0, together they adjust the lens water metabolism, physiological functions and maintain the lens transparency, their abnormal expression can lead to cataracts. We reviewed the research of the water channel protein 0, 1 in recent years and discussed the relationship between water channel protein and cataract.
[中图分类号]
[基金项目]
中国国家自然科学基金面上资助项目(No.81070715)
