[关键词]
[摘要]
目的：评估玻璃体腔内注射曲安奈德(triamcinolone acetonide，TA)治疗视网膜静脉阻塞(retinal vein occlusion，RVO)引起的黄斑水肿的长期安全性与有效性。
方法：患者17例17眼出现视网膜静脉阻塞引起的黄斑水肿，接受玻璃体腔内注射2mg TA，随访1a，监测患者视力、黄斑厚度。
结果：随访发现，15眼(88%)视力得到明显改善，从术前0.114±0.068增加到术后的0.184±0.094，差异有统计学意义(P<0.05)，而中央黄斑区的厚度从术前的514.0±67.4μm减少到术后的442.0±61.5μm，差异有统计学意义(P<0.05)。术后6例患者出现短期眼压升高，并无并发性白内障，玻璃体出血，视网膜脱离以及眼内炎的发生。
结论：玻璃体腔内注射TA能长期有效减缓RVO引起的黄斑水肿。
[Key word]
[Abstract]
AIM: To assess the long-term safety and efficacy of intravitreal triamcinolone acetonide(TA)injection in the management of macular edema caused by retinal vein occlusion(RVO).
METHODS: This prospective, interventional case series included 17 patients(17 eyes)with RVO and macular edema. They received an intravitreal injection of 2mg TA. Follow-up was for 1 year. Outcome measures were visual acuity and macular thickness measured using ocular coherence tomography(OCT).
RESULTS: In our group, visual acuity measurements showed that 15 eyes(88%)had improved visual acuity, and mean visual acuity increased from 0.114±0.068 preoperatively to a postoperative visual acuity of 0.184±0.094(P<0.05). The central macular thickness was reduced from 514.0±67.4μm to 442.0±61.5μm(P<0.05). Six patients in the study suffered a rise in intraocular pressure(IOP)(35%)temporarily. There was no case of visually significant cataract, vitreous haemorrhage, retinal detachment, or endophthalmitis.
CONCLUSION:Intravitreal injection of triamcinolone acetonide can effectively improve the macular edema caused by retinal vein occlusion.
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