方法：选取36例40眼鼻侧初发性翼状胬肉患者，随机分为研究组及对照组，每组20眼。所有患者采用翼状胬肉切除联合自体角膜缘干细胞移植术，术后常规给予妥布霉素地塞米松滴眼液治疗。研究组给予小牛血去蛋白提取物眼用凝胶，对照组给予0.1%透明质酸钠滴眼液。术前及术后3mo采用眼表疾病指数(OSDI)调查表、泪膜破裂时间(BUT)、Schirmer's Ⅰtest(SⅠt)评价干眼严重程度。

结果：研究组与对照组患者年龄、性别、翼状胬肉大小差异无统计学意义(P>0.05)，手术前OSDI评分分别为2.33±1.02，2.32±0.93分； BUT分别为8.80±2.48，8.35±2.28s； SⅠt分别为4.30±2.30，4.40±2.44mm/5min，组间差异无统计学意义(P>0.05)。术后3mo研究组与对照组OSDI评分分别为1.45±0.47，1.81±0.60分； BUT分别为11.20±2.07，9.50±2.40s； SⅠt分别为8.35±3.13，6.35±2.18mm/5min，组间差异有统计学意义(P<0.05)。

结论：小牛血去蛋白提取物眼用凝胶能改善翼状胬肉术后干眼。

METHODS: Thirty six patients(40 eyes)with primary nasal pterygium were enrolled in this study, which were divided into study group and control group randomly, with 20 eyes in each group. All patients received pterygium excision and limbal stem cell autograft surgery and tobramicin dexamethasone eye drops after surgery. Patients of the study group received protein free calf blood extract eye gel while those of the control group received 0.1% sodium hyaluronate eye drops furthermore. Ocular surface disease index(OSDI)questionnaire, tear film break-up time(BUT)and Schirmer's Ⅰ test Ⅰ(SⅠt)were carried before and 3 months after surgery to evaluate the dry eye degree of the patients.

RESULTS: There was no statistical difference between the age, gender and size of the pterygium of the study and control groups preoperatively. There was no statistical difference between the OSDI(2.33±1.02 vs 2.32±0.93), BUT(8.80±2.48 vs 8.35±2.28)seconds and SⅠt(4.30±2.30 vs 4.40±2.44)of the two groups preoperatively. There was statistical difference between the OSDI(1.45±0.47 vs 1.81±0.60), BUT(11.20±2.07 vs 9.50±2.40)seconds and SⅠt(8.35±3.13 vs 6.35±2.18)of the two groups 3 months postoperatively, which was also different from that of the preoperative data correspondingly.

CONCLUSION: Protein free calf blood extract eye gel could reduce the dry eye after pterygium surgery.