方法：2011-09/2012-09我院新生儿监护病房住院诊断为ROP的患儿共145例，其中男110例，女35例，记录其转归情况，对手术组与非手术组的孕周、出生体质量、吸氧时间、吸氧方式(持续正压通气(CPAP)或机械通气)、肺表面活性物质应用、败血症进行统计学分析。

结果：早产儿视网膜病变145例为1～3期患儿，无1例4～5期病变，36例(24.8%)行视网膜光凝或(和)冷凝，109例(75.2%)患儿完全自然退变或阈值前病变病情稳定未手术。采用卡方检验单因素分析及多因素Logistic回归分析，结果表明孕周、吸氧时间、CPAP或机械通气及败血症与ROP转归有关，差异有统计学意义。孕周、吸氧方式、败血症是ROP病情进展的相关因素，组间差异有统计学意义。

结论：ROP大部分可自行退变或病情稳定不需手术，小孕周、机械通气或CPAP、吸氧时间长、败血症可加重病情，增加手术机率。

METHODS: The prognosis of 145 ROP cases treated in our hospital from September 2011 to September 2012 was recorded(110 males, 35 females). Gestational weeks, birth weight, time of oxygen, oxygen \〖continuous positive airway pressure(CPAP)or mechanical ventilation\〗, pulmonary surfactant, septicemia were statistically analyzed between surgical group and non-surgical group.

RESULTS: A total of 145 cases of retinopathy of premature were all in stage 1 to 3, no cases in 4 to 5 stage. Thirty-six cases(24.8%)had undergone the laser and/orcryocoagulation. ROP regressed completely or were stable before prethreshold lesions without surgery in 109 cases(75.2%). Using the Chi-square test, multivariate logistic regression analysis, it showed that gestational age, time of oxygen, CPAP or mechanical ventilation and septicemia were associated with ROP outcome, with the statistically significant difference. Gestational age, oxygen, septicemia were progression factors of ROP, which was significant difference between groups.

CONCLUSION: Most of ROP degenerated or were stable without surgery.Gestational age, mechanical ventilation or CPAP, oxygen for a long time, septicemia could aggravate ROP and increase the probability of surgery.