方法：采用VF/QOL(vision function， VF，视功能； quality of life， QOL，生存质量)问卷调查量表对90例甲状腺相关眼病合并高眼压患者和90例非TAO的患者作为对照组的视觉生存质量进行评价研究。计算两组患者VF/QOL总得分以及各个维度得分。VF 和QOL 问卷测量的指标分别包括主观视觉、周边视野、视觉适应、立体视觉以及自理能力、活动能力、社交能力、心理状态。

结果：TAO合并高眼压的VF(89.93±8.9)和QOL(92.89±5.91)得分均值显著低于对照组(98.18±4.06， 99.21±1.87)，两组间比较差异具有统计学意义(P<0.01)。VF得分中除周边视野外(Z=-0.65，P=0.52)，其他与对照组差异显著(P<0.01)； QOL中各个维度得分均显著低于对照组(P<0.05)。多元线性回归分析发现，病程分级和心理因素均是影响患者VF得分的独立因素，和眼压、年龄、病程等无关，学历是影响QOL得分的因素。

结论：合并高眼压的TAO患者视觉相关生存质量下降和眼压无关，疾病严重程度的分级只会影响到患者的VF得分，和QOL无关。

METHODS: Altogether, 90 TAO patients with intraocular pressure(TAO group)and 90 normal persons(control group)were involved in the investigation. With vision function(VF)questionnaire, their visual perception, peripheral vision, sensory adaptation and depth perception were assessed. With quality of life(QOL)questionnaire, their self-care ability, mobility, social and mental status were assessed. For each group, the total score of VF/QOL and scores of each scale were calculated.

RESULTS: The average total score of VF/QOL in the TAO group was(89.93±8.9, 92.89±5.91)points, which was significantly lower than that in control group(98.18±4.06, 99.21±1.87)points(P<0.01). Except peripheral vision(Z=-0.65, P=0.52), the scores of any other scales in VF in the TAO group were significantly lower than those in control group(P<0.01). Scores of all scales in QOL in the TAO group were remarkably lower than those in control group(P<0.05). In the multiple linear regression analysis, the VF scores were significantly correlated with “NO SPECS'' classification and psychological factors instead of ocular hypertension, age and course of disease, while the scores of QOL were correlated with education background.

CONCLUSION:The VF/QOL in patients with TAO and ocular hypertension is lower, the VF scores were significantly correlated with “NO SPECS” classification instead of ocular hypertension. Intraocular pressure does not affect the vision-related QOL of patients with TAO. The “NO SPECS” classification only affects the scores of VF rather than those of QOL.