方法：1型糖尿病视网膜不同程度病变组40例。对照组30例，对其血清唾液酸水平进行研究。

结果：结果显示，研究组与对照组相比有较高的血清唾液酸浓度(95.95±9.5 vs 45.05±19.91mmoL/L， P=0.0001)。我们也观察到糖尿病性视网膜病变的水平逐步上升，其浓度升高(P<0.05)，但相关性较弱。血清唾液酸浓度与血糖浓度呈正相关(r=0.67， P=0.0001)。

结论：血清唾液酸浓度的增加与视网膜病变阶段有关。这对确定1型糖尿病患者视网膜病变的程度有帮助。但是，仍然需要更详细的研究，以得到更精确的结论。

METHODS: We studied the level of serum sialic acid in 70 patients. Thirty control vs 40 type 1 diabetics and with different levels of diabetic retinopathy as well.

RESULTS:We found higher levels of serum sialic acid level in diabetics compared to control subjects(95.95±9.5 vs 45.05±19.91mmoL/L, P=0.0001). We also observed a progressive rise in its concentration as the level of diabetic retinopathy increased(P<0.05)but the correlation was weak. Serum sialic acid level correlated positively with blood glucose level(r=0.67, P=0.0001).

CONCLUSION: Increase in serum sialic acid levels seems to be related to the stage of the retinopathy and may help us to determine the extent of retinopathy in type 1 diabetic patients. But we think that we need more detailed studies to get a more precise conclusion.