目的：通过评估IOL-Master(光学相干生物测量仪)与传统超声生物测量法联合角膜曲率计测量法对高度近视眼接受白内障超声乳化术后3mo的终视力效果，评价IOL-Master的临床应用价值。

方法：高度近视眼(≥-6.00D)且患有老年性白内障的60眼，随机分为两组，每组30眼，术前分别IOL-Master、超声波生物测量仪联合角膜曲率计测量眼轴长度(L)和角膜曲率(K)，使用SRK/T公式计算人工晶状体度数。对患者施行白内障超声乳化摘除术，按照两种检查法得出的人工晶状体度数植入统一型号的非球面可折叠人工晶状体。术后3mo随诊检查最佳矫正视力、眼屈光度、对比敏感度和波前像差均方根(RMS)。

结果：超声波检查法和IOL-Master检查得出的眼轴分别是29.81±1.53，29.63±1.81mm，两者对比差异有显著性(P=0.001)； 角膜曲率计和IOL-Master测量角膜曲率分别为43.22±1.67，44.27±1.39K，两者对比差异有显著性(P=0.006 )。术后3mo IOL-Master和A超患者平均绝对屈光误差≤±0.50D者分别占63.0%，31.2%，χ²检验差异有显著性(χ²=3.1，P<0.05)。IOL-Master组在夜视及夜视加周边眩光条件下，对比敏感度值明显优于A超组。在瞳孔直径6.0mm条件下IOL-Master组4阶像差、4阶球差、总高阶像差波前像差均方根值低于A超测量组。

结论：IOL-Master是一种高精确性、非接触性、操作简单、安全可靠的人工晶状体度数测量的工具，可以适用于高度近视眼患者白内障术前人工晶状体的设计。

AIM: To evaluate the clinical feasibility of using a new optical coherence interferometry(IOL-Master), comparing with traditional ultrasonic biometry and manual keratometry in the accuracy and characteristics for intraocular lens calculation of high myopia.

METHODS: The measurement of axial length was performed in 60 eyes(30 eyes for each group)with senile cataract of high myopia(≥-6.00D)using IOL-Master and ultrasonic biometry. The measurement of corneal power(K)was also performed in the patient using IOL-Master and manual keratometry preoperatively. Phacoemulsification and foldable lens implantation were done on the patients. IOL power calculation was carried out according to the SRK/T formula on the basis of the group-related data. Best corrected visual acuity, refraction, contrast sensitivity and wave front aberration root mean square(RMS)were re-tested after 3 months postoperatively.

RESULTS: Significant difference between the two methods in axial length measurement which was 29.81±1.53mm by ultrasound and 29.63±1.81mm by IOL-Master(P=0.001). And in corneal power measurement which was 43.22±1.67K by manual keratometry and 44.27±1.39K by IOL-Master(P=0.006). There was a significant difference between the two groups(P=0.001). 63.0% vs 31.2% had a mean absolute refractive error(MARE)within ±0.50 diopter for the IOL-Master and A-scan groups, respectively(χ²=3.1, P<0.05). The RMS values of 4^th order aberration, 4^th order spherical aberration and total high order aberration in the IOL-Master group were lower than those in the A-scan group at 6mm pupil diameter 3 months later.

CONCLUSION: IOL-Master is a non-contact, accurate, safe and reliable tool for calculating IOL power and it is more accurate on the design of the IOL in the cataract surgery on the high myopia patients.