方法：将200例400眼干眼症患者随机分为试验组和对照组，每组各100例200眼。试验组：秦皮滴眼液与0.5g/L环孢素A滴眼液间隔30min，每次1滴点双眼(1mL≈15滴)，各4次/d。对照组仅用0.5g/L环孢素A滴眼液每次1滴点双眼，4次/d。两组均以4wk为一疗程，两组治疗前后均进行基础泪液分泌试验、泪膜破裂时间(BUT)检查，并对结果进行统计分析。

结果：两组用药前Schirmer试验、BUT无统计学差异(P>0.05)； 治疗后两组Schirmer试验、BUT均较治疗前改善，且差异均有显著统计学意义(P<0.01)； 试验组治疗后，Schirmer试验、BUT的改善情况均优于对照组，其差异有显著统计学意义(P<0.01)。

结论：秦皮滴眼液联合环孢素A滴眼液治疗干眼症较环孢素A滴眼液单药使用有更好的治疗效果。

METHODS: Totally, 200 patients(400 eyes)with dry eye syndrome were randomly divided into experiment group and control group, 100 cases(200 eyes)for each. The experiment group was treated by Qinpi eye drops combined with Cyclosporin A eye drops four times per day. The control group was treated by 0.5g/L Cyclosporin A eye drops every 30min only four times per day(one drop per time, 1mL≈15 drops). The Schirmer test(SⅠt), tear film break up time(BUT)were compared with before and after 4 weeks' therapy in both groups. The results were analyzed statistically.

RESULTS: There were significant differences in SⅠt and BUT 4 weeks later after treatment in both groups(P<0.01)whereas no difference before the treatment(P>0.05). There were significant differences in SⅠt and BUT in experiment group compared with control group after 4 weeks(P<0.01).

CONCLUSION: Qinpi eye drops combined with Cyclosporin A eye drops is an effective method for dry eye syndrome.