方法：回顾性分析选取2009-08/2012-08在我院行LASEK治疗的近视患者320例640眼，将患者按年龄分组，18～23岁、24～29岁、30～35岁、大于35岁4组(A，B，C，D)，每组按是否配戴隐形眼镜超过3mo，分为2个亚组(I，II)，统计每组的平均制瓣时间。

结果：大部分患者于术后2～4h后有异物感、疼痛等眼部刺激症状。术后7d左右角膜上皮基本愈合，20d左右视力基本恢复到最佳。术后6mo平均裸眼视力1.23±0.15。制瓣时间11～30(平均18±3.5)s，随着年龄的增加，制瓣时间明显延长，配戴隐形眼镜的时间大于3mo的患者，制瓣时间也明显延长，同年龄段2个亚组(Ⅰ，Ⅱ)作统计学处理，差异有显著性(P<0.05)。同年龄段男、女患者制瓣时间差异不明显(P>0.05)。

结论：随着年龄的增加，制瓣时间明显延长。长期配戴角膜接触镜是影响上皮瓣制作成功的重要因素，配戴隐形眼镜的时间大于3mo的患者，制瓣时间也明显延长。

METHODS:A retrospective analysis from August 2009 to August 2012 in our hospital in 320 cases treated by LASEK in myopic patients(640 eyes), the patients were grouped according to age, 18-23 years, 24-29 years, 30- 35 years, and greater than 35 year were divided into 4 groups(A, B, C, D), each group according to whether wearing contact lenses for more than 3 months, divided into 2 subgroups(I, II), the average flap preparation time statistics for each group.

RESULTS: Most of the patients in postoperative 2-4h after a foreign body sensation, presented ocular pain. Corneal epithelium was basically healed after about 7days. Visual acuity recovered to the best after 20d. After 6 months, the average visual acuity was 1.23±0.15. Flap preparation time 11-30s, average 18±3.5s. With the increase of age, flap preparation time was significantly prolonged. For those wearing contact lens over 3 months, flap preparation time was significantly longer. There was significant difference(P<0.05)after analyzing the same age as 2 subgroups(I, II). Flap preparation time in male and female patients with the same age had no significantly difference(P>0.05).

CONCLUSION: With the increase of age, flap preparation time is significantly prolonged. Long-term wear contact lens is the important factor in the success of production. For those wearing contact lens over 3 months, flap preparation time was significantly longer.