方法：随机选取2012-10/12在重庆爱尔眼科医院行波前像差引导的飞秒激光LASIK手术的高度近视患者(近视-6.0～-10.0DS，散光≤-2.0DC)32例58眼作为试验组。同期接受飞秒激光LASIK手术的高度近视患者(近视-6.0～-10.0DS，散光≤-2.0DC)28例56眼作为对照组。术后随访6mo，比较两组的裸眼视力(uncorrected visual acuity，UCVA)，屈光度数，总高阶像差(high order aberrations，HOA)，球差和彗差。

结果：术后6mo，所有患者UCVA均≥0.8，其中UCVA≥1.0者波前组91.4%，对照组87.5%，差异无统计学意义(P=0.360)； UCVA≥1.2者波前组60.3%，对照组57.1%，差异无统计学意义(P=0.729)； UCVA≥1.5者波前组17.2%，对照组12.5%，差异无统计学意义(P=0.477)。波前组的彗差低于对照组， 差异有统计学意义(P=0.021)。两组UCVA，等效球镜度，总HOA和球差的比较无统计学差异(P>0.05)。

结论：波前像差引导的飞秒激光LASIK手术与常规飞秒激光LASIK手术相比，虽然可以降低术后彗差的产生，但在提高术后UCVA，矫正高度近视度数，降低术后HOA和球差方面没有优势。

METHODS: Thirty-two patients(58 eyes)with high myopia(myopia degree: -6.0～-10.0DS, astigmia degree ≤ -2.0DC)underwent wavefront-guided LASIK using femtosecond laser in Chongqing Aire Eye Hospital from October to December in 2012 were collected as wavefront group, and 28 patients(56 eyes)with high myopia(myopia degree: -6.0～-10.0DS, astigmia degree ≤ -2.0DC)receiving LASIK with femtosecond laser were chosen as control group. These patients were followed up for 6 months. Uncorrected visual acuity(UCVA), refraction, total high order aberrations(HOA), spherical values and coma values between two groups were compared.

RESULTS: Six months after the operation, UCVA of all eyes were higher than 0.8. UCVA achieved 1.0 or better, which account for 91.4% of eyes in wavefront group and 87.5% in control group, the difference was not statistically significant(P=0.360). UCVA achieved 1.2 or better in 60.3% of eyes in wavefront group and 57.1% in control group, the difference was not statistically significant(P=0.729). UCVA achieved 1.5 or better in 17.2% of eyes in wavefront group and 12.5% in control group, the difference was not statistically significant(P=0.477). The coma values were lower in wavefront group than that in control group, the difference was statistically significant(P=0.021). There was no statistically significant difference in postoperative UCVA, refractions, total HOA and spherical values between two groups(P>0.05).

CONCLUSION: Compared with conventional LASIK with femtosecond laser, although wavefront-guided LASIK with femtosecond laser canreduce the coma values of patients with high myopia, wavefront-guided LASIK with femtosecond laser has no adventage in improving UCVA,correcting refractions, reducing the total HOA, and. spherica values.