目的：通过分析儿童眼肌型重症肌无力患儿外周血中免疫球蛋白、补体及T细胞亚群的含量，初步探讨体液免疫和细胞免疫在儿童眼肌型重症肌无力发病中的作用。

方法：采用免疫比浊法检测37例儿童眼肌型重症肌无力患儿及健康对照儿童外周血中IgG，IgA，IgM，补体C3及C4的含量，流式细胞术检测12例儿童眼肌型重症肌无力患儿及健康对照儿童外周血中CD3⁺T淋巴细胞、CD4⁺T淋巴细胞及CD8⁺T淋巴细胞的含量，独立样本t检验进行数据统计分析。

结果：儿童眼肌型重症肌无力患儿外周血IgA，IgM及CD3⁺T淋巴细胞、CD8⁺T淋巴细胞值与健康儿童比较，均无显著性差异(P>0.05)， IgG，补体C3及C4的含量低于健康儿童(P<0.05)。CD4⁺T淋巴细胞值高于对照儿童(P<0.05)。

结论：补体C3，C4及CD4⁺T淋巴细胞在儿童眼肌型重症肌无力的发病机制中起着重要作用。

AIM: To discuss the role of humoral immunity and cellular immunity in the development of ocular myasthenia gravis in children by analyzing the clinical value of the indices including immunoglobulin, complement and T cell subgroup in peripheral blood.

METHODS: The concentrations of serum IgG, IgA, IgM, C3 and C4 in the myasthenia gravis group and the control group were detected by immune compare turbid. The contents of CD3⁺T cell, CD4⁺T cell and CD8⁺T cell were detected by flow cytometry. Data was analyzed by Independent-Sample Test.

RESULTS: There were no significant differences in contents of IgA, IgM, CD3⁺T cell, CD8⁺T cell between ocular myasthenia gravis group in children and the control group(P>0.05). The concentrations of serum IgG, C3 and C4 for myasthenia gravis group were lower than those of the control group(P<0.05). The content of CD4⁺T cell were higher than those of the control group(P<0.05).

CONCLUSION: Complement C3, C4 and CD4⁺T cell played an important role in immunology pathogenesis mechanism for ocular myasthenia gravis in children.