[关键词]
[摘要]
目的：利用磁共振扩散张量成像(diffusion tensor imaging，DTI)技术研究单眼弱视儿童治疗前后视放射的变化及其神经机制。
方法：选择18例左眼屈光参差性弱视儿童经过为期9mo的弱视治疗，对治疗前后的视放射进行DTI检查，比较分析治疗前后视放射的各向异性分数(fractional anisotropy， FA)值和表观扩散系数(apparent diffusion coefficient， ADC)值的变化。
结果：治疗后两侧视放射的FA 值均高于治疗前(P<0.05)，ADC值均低于治疗前(P<0.05)。右侧视放射治疗前后FA 值和ADC值的变化均大于左侧视放射(P<0.05)。
结论：单眼弱视儿童经过有效的弱视治疗后，两侧视放射的神经纤维均得到不同程度的改善。
[Key word]
[Abstract]
AIM: To investigate the alterations of optic radiations(ORs)in monocular amblyopic children underwent treatment by using diffusion tensor imaging(DTI),and to explore its underlying neuromechanism.
METHODS: Eighteen children with anisometropic amblyopia(all left eyes)were recruited for amblyopia therapy. DTI data of ORs were acquired for each patient twice: before and after 9mo amblyopia therapy. The fractional anisotropy(FA)values and apparent diffusion coefficient(ADC)values were campared between the previous and posterior scans.
RESULTS: On both sides of ORs, the FA values of posterior therapy were higher than those of previous therapy(P<0.05), while the ADC values of posterior therapy were lower than those of previous therapy(P<0.05). The alterations of FA values and ADC values of ORs on the right side were greater than those of ORs on the left side after therapy(P<0.05).
CONCLUSION: Both sides of ORs in monocular amblyopic children are modified to varying degrees after myopia therapy.
[中图分类号]
[基金项目]
2011年深圳市科技计划项目(No.201103146)
