目的：比较光学相干断层扫描(optical coherence tomography，OCT)、角膜内皮计与超声测厚仪测量准分子激光上皮下角膜磨镶术(laser subepithelial keratomileusis， LASEK)术后患者中央角膜厚度(CCT)的差异性和相关性。

方法：选取LASEK术后6mo复诊的近视患者49例96眼，对每位患者分别用OCT、角膜内皮计、超声测厚仪三种仪器测量其CCT，数据统计分析采用配对t检验和Pearson 相关性分析。

结果：OCT、角膜内皮计、超声测厚仪测量CCT的平均值为分别为475.15±33.67，447.80±34.11，465.18±34.23μm。手术预留CCT平均值为431.22±35.32μm。三种仪器所测量结果之间两两比较差异均有统计学意义(P<0.05)。线性相关显示超声测厚仪与OCT、角膜内皮计两种仪器之间存在正相关(r=0.949，0.983 ，P<0.01)。LASEK术后实际CCT较手术预留角膜厚度要厚。

结论：三种仪器的中央角膜厚度测量值不可互换。

AIM: To compare the differences and the relationships of central corneal thickness(CCT)measurements among optical coherence tomography(OCT), Tomey pachymetry and ultrasound pachymetry after laser assisted subepithelial keratomileusis(LASEK).

METHODS:Forty-nine patients(96 eyes)with myopia after 6mo of LASEK were assigned to measure the CCT by OCT, Tomey pachymetry and ultrasound pachymetry. Paired t-test and Pearson correlation analysis was used for statistical analysis.

RESULTS: The mean CCT measured by OCT, Tomey pachymetry and ultrasound pachymetry was(475.15±33.67μm),(447.80±34.11μm),(465.18±34.23μm), respectively. Surgery reserved mean CCT was(431.22±35.32)μm. There were statistically differences between two comparative measured results(P<0.05). Ultrasound pachymetry had a positive correlation with OCT and Tomey pachymetry(P<0.01), and the correlation coefficient was 0.949 and 0.983, respectively. The actual CCT of 6mo post-operation was thicker than surgery reserved CCT.

CONCLUSION: The CCT measurements of three instruments were not interchangeable.