方法：将2010-01/2013-01期间本院收诊的难治性青光眼患者随机分成两组，对照组和观察组各80例。所有患者均行复合式小梁切除术，观察组患者在此基础上口服丝裂霉素C治疗。比较两组间疗效及治疗前后眼压、视力差异； 比较治疗前后两组间血清叶酸(FA)、维生素 B12(VB12)、维生素 B6(VB6)及白介素-2(IL-2)、白介素-6(IL-6)水平差异。

结果：观察组手术成功率为80.9%，显著高于对照组的60.7%，术后观察组眼压显著低于对照组，视力显著高于对照组(P<0.05)。手术未成功组患者血清FA，VB12，IL-2，IL-6显著低于正常对照组和手术成功组(P<0.05)。术后3mo观察组患者血清FA，VB12，IL-2，IL-6显著高于对照组(P<0.05)。

结论：在复合式小梁切除术中加载丝裂霉素C能有效提高难治性青光眼的治疗成功率，改善血清维生素、白介素相关指标。

METHODS: Patients with refractory glaucoma from January 2010 to January 2013 were randomly divided into control group(compound trabeculectomy treatment group)with 80 cases and observation group(MMC combined with compound trabeculectomy treatment group)with 80 cases, then the difference in efficacy between the two groups were counted, and the intraocular pressure, visual acuity and the levels of FA, VB12, VB6, IL-2 and IL-6 of two groups before and after the treatment were also been compared.

RESULTS: The surgical success rate of observation group was 80.9% which was significantly higher than that of control group(60.7%); after the surgery, the intraocular pressure of observation group were all lower than that of control group, and the visual acuity was better than that of control group, all P<0.05. The levels of FA, VB12, IL-2 and IL-6 of failed surgery group were significantly lower than that of control group and successful surgery group(P<0.05). The levels of FA, VB12, IL-2 and IL-6 of observation group at 3mo after the treatment were all higher than those indexes of control group,all P<0.05.

CONCLUSION: Combined with MMC could effectively improve surgical success rate of refractory glaucoma, and improve the indicators of serum vitamin, interleukin.