方法：采用角膜内皮显微镜对 65例130眼不同程度糖尿病性视网膜病变患者(均为2型糖尿病患者)及年龄、性别相匹配的35例70眼正常健康人进行中央角膜厚度检测，并对结果进行统计分析。

结果：轻度、中度非增生期糖尿病视网膜病变(NPDR)组与对照组比较，中央角膜厚度差异无统计学意义(P>0.05)，而重度NPDR组和增生期糖尿病视网膜病变(PDR)组的CCT较对照组增厚，差异有统计学意义(P<0.05)； 组间比较中：轻度NPDR组与重度NPDR组和PDR组比较，差异有统计学意义(P<0.05)，中度NPDR组与PDR组比较，差异有统计学意义(P<0.05)； 且CCT随DR的程度加重而增厚，呈正相关(r=0.173，P<0.05)。

结论：糖尿病性视网膜病变的中央角膜厚度随着病变加重逐渐增厚。DR患者治疗过程中，尤其是内眼手术时应特别注意保护角膜内皮，减少并发症的发生。

METHODS: A total of 65 cases(130 eyes)with different degrees of DR and 35 normal cases(70 eyes)as the age-and gender-matched control group were examined by corneal endothelial microscope, to measure CCT and statistics

RESULTS: Compared to control group, there were no significant difference of CCT both mild and medium nonproliferative diabetic retinopathy(NPDR)groups(P>0.05). While the CCT of severe NPDR group and proliferative diabetic retinopathy(PDR)group were thicker than control group, and the differences were statistically significant(P<0.05); Pairwise comparison in different degrees of DR groups: the CCT of severe NPDR and mild NPDR groups were thicker than PDR group, and the differences were statistically significant(P<0.05); compared to medium NPDR, the CCT of PDR was thicker(P<0.05); The thickness of CCT increases with severity of DR, there was positive linear correlation(r=0.173, P<0.05).

CONCLUSION: The CCT increases with severity of DR. Taking care of protecting corneal endothelium is very important in the time of therapeutic measure, especially intraocular operation, to decrease complication.