方法：随机选取30例60眼屈光参差性弱视患儿作为试验组。29例58眼双眼矫正视力均正常的儿童为对照组。采用OCT-3测量试验组和对照组儿童黄斑A1区视网膜厚度，进行动态观察并行相关分析。

结果：对照组黄斑A1区视网膜厚度3，6mo时与初诊比较差异均有统计学意义； 试验组又分为弱视眼组和非弱视眼组，非弱视眼组黄斑中心凹视网膜厚度3，6mo时与初诊比较差异均有统计学意义，弱视眼组按治疗效果分为无效组、进步组、基本治愈组，无效组和进步组黄斑A1区视网膜厚度3，6mo时与初诊比较差异均无统计学意义； 基本治愈组黄斑A1区视网膜厚度3mo与初诊比较差异无统计学意义，但6mo与初诊比较差异有统计学意义。

结论：屈光参差性弱视儿童黄斑A1区视网膜厚度在弱视治疗前后的变化与弱视治疗效果有一定关系。OCT技术是一种客观的辅助检测方法，可为弱视的研究提供新线索。

METHODS: Through randomly selecting 30 cases(60 eyes)of anisometropic amblyopic children as test group and 29 cases(58 eyes)of children with normal vision after the vision correction as control group, the changes of the retinal thicknesses of macular of the test group and the control group at Area A1 by OCT-3 was observed dynamically and analyzed.

RESULTS:Compared with first diagnosis, the comparative difference of retinal thicknesses of macular at Area A1 in control group at 3, 6mo has statistical significance. The test group was divided into amblyopia group and non-amblyopia group. There has statistical significance for the comparative difference between the retinal thicknesses of macular centre at 3, 6mo and the first diagnosis in the non-amblyopia group, the amblyopia group was divided into the invalid cure group, progress group and the cured group according to amblyopic cure effect. Compared with first diagnosis, there is no statistical significance of macular at Area A1 in invalid cure group and progress group at 3, 6mo, and in the cured group at 3mo, but in the cured group at 6mo has statistical significance.

CONCLUSION: There is a certain relationship between the changes of retinal thicknesses of macular of children with anisometropic amblyopic at Area A1 before and at the end of amblyopia treatment and amblyopia cure effect. OCT is a kind of objective auxiliary test method and provides new clues for amblyopia research.