目的：研究转化生长因子β1(transforming growth factor -β1，TGF-β1)和热休克蛋白47(heat shock protein 47，HSP-47)在翼状胬肉和正常结膜组织表达的差异，从而探讨它们在翼状胬肉发生、发展中的作用，为翼状胬肉的治疗提供新的方向。

方法：采用免疫组化方法比较翼状胬肉和正常结膜组织中TGF-β1和HSP-47的表达差异。

结果：TGF-β1在翼状胬肉的鳞状上皮细胞中的表达水平明显高于正常结膜组织，在其基质层和内皮层有中等量表达，同时，在翼状胬肉纤维层的炎性细胞和血管内皮细胞中TGF-β1也有明显表达。与此相反，在正常结膜组织中TGF-β1表达较弱。HSP-47在翼状胬肉的固有层高表达，在上皮细胞表达较弱，在正常结膜组织中则未见明显表达。

结论：相比正常结膜组织，TGF-β1和HSP-47均在翼状胬肉组织中有较高水平的表达，因此推测二者在诱导翼状胬肉的发生、发展中起着重要的作用。

AIM:To investigate the expression transforming growth factor-β1(TGF-β1)and heat shock protein 47(HSP-47), in pterygium and normal conjunctiva tissues, in order to study the roles of these cytokines played in the pathogenesis in human pterygium.

METHODS:The expression difference of TGF-β1, HSP-47 between human pterygium and normal conjunctive tissues were compared by immuno-histochemistry technique.

RESULTS:The positive expression of TGF-β1, HSP-47 was stronger than in normal conjunctive tissues(P<0.05), the TGF-β1 expressed in all layers of pterygium, especially in the squamous epithelium, in the inflammation cells and vascular endothelial cells also expressed. The HSP-47 showed higher expressed in the lamina propria layer of pterygium, and weakly expressed in epithelial layer, no obvious expression in normal conjunctive tissues.

CONCLUSION:Over-expression of TGF-β1 and HSP-47 in pterygium compared to the normal conjunctiva tissues may play a critical role during the occurrence, development and invasion of the pterygium.