方法：对55例60眼行胬肉切除联合自体角膜缘干细胞移植手术治疗的初发性翼状胬肉患者，随机分为试验组(表面麻醉组)27例30眼和对照组(局部麻醉组)28例30眼。试验组给予常规奥布卡因表面麻醉后进行胬肉切除联合自体角膜缘干细胞移植术； 对照组给予20g/L利多卡因局部麻醉试验后进行胬肉切除联合自体角膜缘干细胞移植术。试验组及对照组均采用黏合剂将植片与植床进行粘贴(黏合剂为凝血酶溶液及含有因子Ⅷ和抑肽酶的纤维蛋白溶液)。术后随访6mo，主要观察手术时间，植床与植片的匹配程度及术中与术后患者的疼痛评分。

结果：试验组手术时间相对较短，差异有统计学意义(P=0.008)，试验组植床与植片匹配度(93%)优于对照组(83%)，具有统计学差异(P<0.05)。

结论：奥布卡因表面麻醉下使用纤维蛋白胶黏合剂完全能满足胬肉切除联合自体角膜缘干细胞移植术的要求，且能使植床与植片更好匹配，缩短了手术时间。

METHODS: A prospective randomised clinical trial was carried out in 60 eyes of 55 patients operated for primary nasal pterygium, which were divided into two groups randomly: experimental group(30 eyes in 27 patients)was under surface anesthesia(oxybuprocaine)and control group(30 eyes in 28 patients)was under local anesthesia(20g/L lidocaine). Autologous limbal graft taken from the superotemporal limbus was used to cover the sclera by a fibrin tissue adhesive after pterygium excision. Patients were followed up at least for 6mo. Time of operation, matching degree of graft and VAS score were mainly observed and recorded.

RESULTS: In experimental group the average surgery time was shorter(P=0.008)and matching degree of graft(93%)was better than control group(83%), the differences had statistical significance(P<0.05).

CONCLUSION: The surface anesthesia is enough when using fibrin glue for graft fixation in pterygium surgery, which will shorten surgery time and get better matching degree of graft.