方法：观察2009-10/2013-10本院90例确诊为糖尿病性视网膜病变患者，回顾性分析患者黄斑水肿程度与血清可溶性E-选择素(sE-sel)水平相关性。按是否发生糖尿病黄斑水肿将诊断为糖尿病视网膜病变患者分为两组，糖尿病黄斑水肿组和非糖尿病黄斑水肿组，比较两组血清sE-sel、尿微量蛋白(MA)水平。

结果：组间比较MA，sE-sel差异有统计学意义(P<0.05)，DME患者sE-sel水平与MA、空腹血糖(FBG)成正相关(r=0.728，P<0.05； r=0.651，P<0.05)。

结论：血清可溶性E-选择素水平升高是糖尿病性黄斑水肿的危险因素，参与了糖尿病微血管病变的发病机制。

METHODS: Totally 90 patients with diabetic retinopathy in our hospital from October 2009 to October 2013 were observed. Retrospective analysis of the correlation between macular edema degree and serum soluble E-selectin(sE-sel). Ninety patients with diabetic retinopathy were divided into two groups: DME group and non-DME group. The level of sE-sel and microalbuminuria(MA)of two groups were determined and compared.

RESULTS: There was significant difference in MA, sE-sel levels of groups(P<0.05). The value of diabetic retinopathy patients with sE-sel and MA, FBG were positively correlated(r=0.728, P<0.05; r=0.651, P<0.05).

CONCLUSION: Elevated levels of sE-sel is a risk factor for diabetic macular edema, and sE-sel was involved in the pathogenesis of diabetic microangiopathy.