方法：回顾性分析150例300眼近视患者，根据制作角膜瓣方法不同分为两组，组1为飞秒激光(Intralase FS60KHz)制作角膜瓣，95例190眼； 组2为Moria M₂ 90号板层刀制瓣，55例110眼。观察两组术前、术后1wk； 1，3，6mo患者的干眼症状评分、泪膜破裂时间(tear break-up time，BUT)、泪液分泌试验(Schirmer I test，S I t)、角膜荧光素染色(corneal fluorescence staining，FL)评分的变化。

结果：干眼症状评分：两组术后1wk； 1，3mo差异有统计学意义(P<0.05)，术后6mo差异无统计学意义(P>0.05)。BUT：两组术后1wk； 1，3mo差异有统计学意义(P<0.05)，术后6mo差异无统计学意义(P>0.05)。SchirmerⅠ试验：两组术后1wk； 1，3mo差异有统计学意义(P<0.05)，术后6mo差异无统计学意义(P>0.05)。荧光素染色评分：两组术后1wk； 1，3mo差异有统计学意义(P<0.05)，术后6mo差异无统计学意义(P>0.05)。

结论：飞秒激光和角膜板层刀制瓣LASIK术后早期泪膜功能减退，但飞秒激光制瓣术后泪膜功能恢复更快。

METHODS: Totally 150 patients(300 eyes)with myopia received operation of LASIK. Patients were divided into two groups according to the methods of making corneal flap. The patients of group one were assigned to receiving LASIK with corneal flap creation by Intralase femtosecond laser(190 eyes of 95 patients), group two were assigned to receiving LASIK with corneal flap creation by microkeratome(110 eyes of 55 patients). Dry eye symptom score, tear break-up time(BUT), Schirmer Ⅰ test(S I t), corneal fluorescein staining(FL)were recorded preoperatively and postoperatively at 1wk; 1, 3 and 6mo.

RESULTS: Dry eye symptom score: there existed obvious differences at 1wk; 1, 3mo between two groups(P<0.05). While no such obvious differences existed in the 6mo between two groups(P>0.05). BUT: there existed obvious differences at 1wk, 1, 3mo between two groups(P<0.05). While no such obvious differences existed at 6mo between two groups(P>0.05). SchirmerⅠ test: there existed obvious differences in the 1wk, 1, 3mo between two groups(P<0.05). While no such obvious differences existed in the 6mo between 2 groups(P>0.05). FL: there existed obvious differences in the 1wk, 1, 3mo between two groups(P<0.05). While no such obvious differences existed in the 6mo between two groups(P>0.05).

CONCLUSION: The early stability of tear film decrease after operation in both of the two groups. The dry eye symptoms are lighter and recover faster.