目的：应用频域光学相干断层扫描(fourier-domain optical coherence tomography， FD-OCT)动态观察急性中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy，CSCR)氪激光治疗后光感受器层形态学变化，并探讨其与视力变化的相关性。

方法：回顾性病例系列研究。临床诊断为单眼初次发病的中心性浆液性脉络膜视网膜病变患者52例，氪激光治疗前、治疗后1，2，4，6，8wk； 6mo分别行FD-OCT检查，观察其光感受器层形态学变化特征及视力变化。

结果：所有病例治疗后1wk均好转； 2wk 6例治愈； 4wk 38例治愈，6wk 41例治愈，8wk 45例治愈，OCT显示黄斑区视网膜神经上皮(retinal neuroepithelial layer， RNL)层脱离完全吸收； 6mo与8wk时相同。患者治疗前后最佳矫正视力及黄斑区RNL脱离高度差异有统计学意义(P<0.05)，治疗后视力变化与黄斑区RNL脱离高度有相关性，光感受器层完整者与不完整者最佳矫正视力差异有显著统计学意义(P<0.01)。

结论：FD-OCT可动态观察急性中心性浆液性脉络膜视网膜病变氪激光治疗后光感受器超微结构变化，光感受器层完整者与不完整者最佳矫正视力差异有显著统计学意义(P<0.01)。

AIM: To dynamically observe the feeling change of the photorecrptor layer in the eyes with acute central serous chorioretinopathy(CSCR)krypton laser treatment by fourier-domain optical coherence tomography(FD-OCT), and to study their correlation with the chang of vision.

METHODS: This is a retrospective case series study. The clinical diagnosis of 52 patients with monocular initial onset of central serous chorioretinopathy, krypton laser photocoagulation before treatment, after 1, 2, 4, 6, 8wk, 6mo, FD-OCT were performed to observe the morphological changes characteristic of photoreceptor layer and changes in vision.

RESULTS: After 1wk treatment, all cases were improved; 2wk, 6 cases were cured; 4wk, 38 cases were cured; 6wk, 41 cases were cured; 8wk, 45 cases were cured, the OCT showed macular retinal neuroepithelial layer(RNL)from fully absorbed; 6mo with the same 8wk. Before and after treatment in patients with best corrected visual acuity and from the height difference between the macular region of RNL was statistically significant(P<0.05), there was a correlation between the changes of visual acuity after treatment and the macular detachment of RNL height(P<0.05), Photoreceptor layer of complete and incomplete best corrected visual acuity difference was statistically significant(P<0.01).

CONCLUSION: FD-OCT can dynamicaly observed acute central serous chorioretinopathy krypton laser treatment of photoreceptor ultrastruture changes. Photoreceptor layer of complete and incomplete best corrected visual acuity difference was statistically significant(P<0.01).