方法：功能性泪溢患者100例200眼，正常对照20例40眼。观察指标包括Schirmer Ⅰ试验、按压泪囊部时Schirmer Ⅰ试验、泪膜破裂时间，同时采用ELISA测定功能性泪溢患者泪液主要蛋白含量，并与正常人的泪液对比。

结果：正常受试者按压泪囊部时与开放泪囊部时的Schirmer Ⅰ测试值比较，差异有显著意义(t=-4.008，P<0.05)，而功能性泪溢患者在不同时间点的Schirmer Ⅰ试验测试值比较，差异无显著意义(t=-0.811，P>0.05)。功能性泪溢患者泪膜破裂时间缩短(t=-5.382，P<0.01)，功能性泪溢组与对照组泪液蛋白含量比较，溶菌酶、白蛋白浓度降低(P<0.05)，乳铁蛋白、分泌型免疫球蛋白A含量无明显差异(P>0.05)。

结论：泪道泵功能破坏在功能性泪溢中存在重要影响，功能性溢泪患者泪液蛋白质发生变化。

METHODS: One hundred cases(200 eyes)with functional epiphora and 20 cases(40 eyes)of nonfunctional controls were recruited and under routine ophthalmic examinations, including Schirmer I test, Schirmer I test while pressing the lacrimal sac, tear film break-up time(BUT). Enzyme linked immunosorbent assay(ELISA)was used to detect main tear proteins, and the results were compared with control group.

RESULTS: Compared the result of the Schirmer I test on the normal subjects while pressing the lacrimal sac with that of releasing the lacrimal sac, the difference was significant(t=-4.008, P<0.05). While the result on the functional epiphora group showed no significant difference(t=-0. 811, P>0.05). The mean BUT was significantly shorter than that in the normal subjects(t=

-5.382, P<0.01). The concentrations of lactoferrin and albumin in the functional epiphora group decreased significantly(P<0.05), and the concentrations of Lactoferrin and secretory IgA didn't show significant(P>0.05).

CONCLUSION: The damage of lacrimal pump function plays a great role in the functional epiphora and the tear proteins of functional epiphora patients changed.