目的：飞秒微透镜切除术(femtosecond lenticule extraction，FLEx)治疗中高度近视及近视散光并与标准的准分子激光原位角膜磨镶术(laser in situ keratomileusis，LASIK)比较并随访观察6mo，证实飞秒微透镜切除术提高患者术后视觉质量更有优越性。

方法：随机选取行角膜屈光手术的中高度近视及近视散光(球镜度数-3.00～-10.00D，散光度≤-6.0D)患者共86例172眼，分为两组进行研究，86眼使用FLEx(A组)，86眼使用标准的LASIK(B组)，跟踪随访6mo，记录术后总高阶像差、球差、裸眼视力、最佳矫正视力、客观验光值、裂隙灯检查、术后有无并发症、眼压、角膜地形图。

结果：所有患者手术均成功，FLEx术后总高阶像差和球差的增加量较LASIK术少。

结论：飞秒微透镜切除术矫正高度近视和近视散光在提高视觉质量方面有明显优越性。

AIM: To discuss the subjective visual sensation of femtosecond lenticule extraction(FLEx)in treatment of moderate and high myopia and myopic astigmatism for 6mo follow-up, compare the efficacy with standard laser in situ keratomileusis(LASIK)and confirm FLEx had more advantages on improving visual quality after surgery.

METHODS: In a prospective study 86(172 eyes)moderate and high myopia and myopic astigmatism patients were involved. The myopia degree was -3.00～-10.00D, the astigmatism degree ≤-6.00D. Eighty-six eyes were treated with FLEx in group A, and 86 eyes were treated with LASIK in group B. All patients in the treatment group completed the final 6mo of follow-up. The higher-order aberrations and the uncorrected visual acuity(UCVA)and the best spectacle-corrected visual acuity(BSCVA), objective and manifest refractions, results of slit-lamp examination, the side effects, the corneal flap thickness, intraocular tensionare, corneal topography were noted.

RESULTS: All of operations on 172 eyes were successful without severe complications after 6mo follow-up. The total higher order aberration and spherical aberration induced by FLEx were lower than that by LASIK.

CONCLUSION:FLEx for high myopia and myopic astigmatism has obvious superiority in the aspect of improving visual quality.