方法：将接受眼科A超检查的住院患者随机分为5g/L丁卡因组(50例50眼)、20g/L利多卡因组(60例60眼)和5g/L爱尔凯因组(60例60眼)。于A超检查前15min每间隔5min点1次表面麻醉剂后行角膜荧光素染色，记录并评估角膜上皮的损伤情况。

结果：χ²检验结果显示：对爱尔凯因组与利多卡因组及丁卡因组角膜荧光素染色(corneal fluorescein staining，CSF)评分差别有统计学意义(P<0.05)，5g/L爱尔凯因对角膜的损伤程度明显低于其他两组。

结论：表面麻醉药可对角膜造成不同程度的毒性损伤，其中爱尔凯因对角膜的毒性最小。

METHODS: Subjects who accepted A ultrasound examination were randomly divided into three groups: 5g/L tetracaine group(n=50), 20g/L lidocaine group(n=60)and 5g/L Aier Kai genome group(n=60). The patients were instructed to use the surface anesthetics three times in a five minute interval before the A ultrasound examination. Corneal epithelial injury was measured by corneal fluorescein staining.

RESULTS: χ² test results showed the CSF score of three groups had significant difference(P<0.05). The extent of damage to the cornea in the 5g/L Aier Kai genome group was significantly lower compared with the others(P<0.05).

CONCLUSION: Varying degrees of damage to the corneal epithelium caused by surface anesthetics and toxic effects of 5g/L Aier Kai genome on the corneal epithelium is minimum.