方法：横断面研究。无糖尿病正常人30例30眼(对照组)； 内分泌科确诊为2型糖尿病，经检眼镜、眼底荧光血管造影检查无视网膜病变(NDR)患者35例35眼； 非增殖性糖尿病视网膜病变(non-proliferative diabetic retinopathy，NPDR)患者38例38眼。分别对其行多焦视网膜电图(multifocal retina electroretinogram，mf-ERG)、对比敏感度(contrast sensitivity，CS)及视网膜中央动脉彩色多普勒检查。采用单因素方差分析及SNK-q法进行统计学分析。

结果：NDR患者即出现P1波振幅下降，N1波潜时延长，且与视网膜病变程度相关(P<0.05)； NDR患者CS值在中、高频段出现下降(P<0.05)，NPDR患者CS值全频段下降(P<0.05)； 视网膜中央动脉(CRA)血流在对照组与NDR组间差异无统计学意义(P>0.05)，在对照组、NDR组与NPDR组间差异有统计学意义(P<0.05)。

结论：mf-ERG和CS是糖尿病患者早期视功能评价的敏感指标，随着病变发展CRA血流也出现改变。

METHODS: This was cross sectional study,multifocal retina electroretinogram(mf-ERG), contrast sensitivity(CS)and central retinal artery color Doppler examination were recorded from 30 cases(30 eyes)matched control subjects, 35 cases(35 eyes)with type 2 diabetes mellitus(DM)without diabetic retinopathy(NDR)and 38 cases(38 eyes)with non-prolifera tive diabetic retinopathy(NPDR). One-way ANOVA and SNK-q test were used for data analysis.

RESULTS: P1 response density of NDR patients were found decrease, N1 implicit time were delayed. Which were related with the degree of retinopathy(P<0.05); CS of NDR patients were found significant in middle and high frequency(P<0.05), NPDR patients were found significant in full frequency(P<0.05); Central retinal artery(CRA)blood flow in the control groups and NDR groups were not found statistically significant(P>0.05), The differences between normal group, NDR group and NPDR group were found statistically significant(P<0.05).

CONCLUSION: mf-ERG and CS are sensitive indexes for early evaluation of visual function in patients with diabetes mellitus, with development of the disease, CRA blood flow also appears to decline.