方法：原发性青光眼患者57例95眼随机分为两组，为小梁切除术联合MMC(T+MMC)组(31例54眼)和小梁切除术(T)组(26例41眼)，术后随访4～6mo，观察其前房、滤过泡、眼压及并发症。

结果：T+MMC组术后1d平均眼压为11.24±3.73mmHg，较术前眼压明显降低(P< 0.01)，与T组比较差异无统计学意义(P>0.05)。而末次随访平均眼压为16.15±3.62mmHg，与T组(18.79±5.27mmHg)比较具有统计学差异(P<0.05)。T+MMC组和T组功能性滤过泡形成率分别为94.44%和80.48%，组间差异具有显著统计学意义(P<0.01)。两组偶发前房出血、角膜水肿，均治愈。

结论：采用小梁切除术联合MMC治疗青光眼，术后眼压控制及滤过泡形态维持均良好，并发症少。

METHODS: A total of 57 patients(95 eyes)of primary glaucoma were randomly divided into two groups, 31 patients(54 eyes)in trabeculectomy with MMC(T+MMC)group, which received trabeculectomy with 0.2mg/mL MMC in surgical sites, and 26 patients(41 eyes)in trabeculectomy(T)group. The anterior chamber, bleb, intraocular pressure(IOP)and complications were observed. The post-operative follow-up periods ranged between 4 and 6mo.

RESULTS: The mean IOP was 11.24±3.73mmHg on 1d in group T+MMC. There was the significant difference compared with preoperative IOP(P<0.01), while no difference with the group T(P>0.05). At final follow-up, the IOP was significantly different between group T+MMC and group T(16.15±3.62mmHg vs 18.79±5.27mmHg, P<0.05). The rate of bleb formation was 94.44% and 80.48% in group T+MMC and T, respectively(P<0.01). The postoperative complications were seldom, hyphema and corneal edema, and were cured finally.

CONCLUSION: Trabeculectomy with MMC for glaucoma can effectively reduce postoperative scar formation of the filtration passage and lower the IOP to a target level with fewer complications.