方法：将我院诊治的91例青光眼患者随机分为三组，A组30例术中应用丝裂霉素，B组31例术中应用5-氟尿嘧啶，C组30例术中应用环胞霉素。术后随访1a，记录手术成功率、1a不良反应发生率、视力、眼压情况、低眼压、浅前房、角膜损害等指标情况。

结果：A，B，C三组眼压分别为20.5±8.6mmHg，15.2±5.5mmHg，20.0±8.1mmHg，经方差分析，B组显著低于其他两组(P<0.05)； A，B，C三组患者1a后视力提高比率分别为22.5%，38.1%，23.1%，经卡方检验，B组提高比例显著高于其他两组(P<0.05)； A，B，C三组患者1a后手术成功率分别为67.5%，88.1%，71.8%，经卡方检验，B组手术成功率显著高于其他两组(P<0.05)； 总不良反应发生率分别为22.5%，9.5%，20.5%，经卡方检验，B组显著低于其他两组(P<0.05)。

结论：青光眼滤过术中联合应用5-氟尿嘧啶可以提高手术成功率，减少不良反应的发生率，安全性较高。

METHODS:A total of 91 cases of patients with glaucoma treated in our hospital were randomly divided into three groups, 30 cases of group A were given mitomycin in surgery, 31 cases of group B were given 5-fluorouracil, 30 cases of group C were given cyclosporine. They were given 12 -month-follow-up after operation, the operation success rate were recorded, the incidence of 1 -year-adverse reactions, visual acuity, intraocular pressure, low intraocular pressure, shallow anterior chamber, corneal damage index were recorded.

RESULTS: Intraocular pressure ofgroups A, B, C were respectively(20.5±8.6)mmHg,(15.2±5.5)mmHg,(20.0±8.1)mmHg,by the analysis of variance, group B was significantly lower than other two groups,P<0.05; patients of groups A, B, C whose visual acuity increased ratios after 1y were respectively 22.5%, 38.1%,and 23.1%, by the Chi. square test, the increased ratio of group B was higher than other two groups, P<0.05; The operation success rates after 1y of operation of groups A, B, C were respectively 67.5%,88.1%,71.8%,by the Chi square test, the increased ratio of group B was higher than other two groups, P<0.05; The general incidence of adverse reaction were respectively 22.5%,9.5%,20.5%,by the Chi square test, the increased ratio of group B was lower than other two groups, P<0.05.

CONCLUSION:Glaucoma filtration surgery combined with the application of 5-fluorouracil can improve the operation success rate, decrease the occurrence rate of adverse reaction, and safety can be improved.