方法：选择2011-12/2014-06入住我院的28例行青光眼白内障联合手术青光眼患者作为观察组，同时选择28例未行手术治疗的青光眼白内障患者作为对照组，选择同期在我院进行体检的30名健康者作为健康对照组。比较三组受试者术前1d； 术后3，6mo时的泪液MUC5AC水平及眼表功能评分。

结果：两组患者术前泪液NUC5AC含量明显低于健康对照组(P<0.05)，眼表功能评分明显高于健康对照组(P<0.05)。观察组术后1mo泪液MUC5AC水平显著低于术前(P<0.05)，术后3mo MUC5AC含量逐渐升高至术前水平，术后6mo时泪液MUC5AC水平均显著高于术前(P<0.05)； 术后1mo眼表功能评分显著高于术前(P<0.05)，术后3mo时，眼表功能评分逐渐降低，术后6mo时眼表功能评分均显著低于术前(P<0.05)。而对照组在术后6mo期间，随着时间的推移，泪液MUC5AC含量逐步降低，眼表功能评分逐步升高。

结论：青光眼白内障联合手术术后可使青光眼患者MUC5AC水平暂时性降低，眼表功能评分暂时性升高，但术后3mo后，可逐步改善。

METHODS: Twenty-eight patients treated with glaucoma and cataract combined surgery were chosen as the observation group from December 2011 to June 2014 in our hospital, and other 28 cases of glaucoma and cataract did not undergo surgical treatment were selected as the control group, 30 healthy subjects were as healthy control group. the MUC5AC level and ocular surface score of the three subjects before surgery 1d, after 3 and 6mo were compared.

RESULTS: The NUC5AC of the two groups of patients was significantly lower than that of the healthy control group before surgery(P<0.05), the ocular function score was significantly higher than the healthy control group(P<0.05). After 1mo, the MUC5AC of the observation group were significantly lower than that of before surgery(P<0.05), after 3mo MUC5AC content gradually increased to preoperative levels, after 6mo the MUC5AC were significantly higher than before surgery(P<0.05). After 1mo, ocular function scores were significantly higher than the preoperative(P<0.05), while after 3mo, ocular function scores decreased after 6mo of ocular surface function scores were significantly lower than the preoperative(P<0.05). While the control group after 6mo, with the passage of time, the MUC5AC content gradually reduce, ocular function score increased gradually.

CONCLUSION: To treat the patients with glaucoma and cataract with combined surgery, the level of MUC5AC can temporary decrease. Ocular function score can temporary increase in, but after 3mo, it can be gradually improved.