方法：对我院61例122眼慢性肾功能衰竭患者(CRF组)，与61例健康人员(对照组)两组人员进行泪液分泌试验(Schirmer Ⅰ test，SⅠt)，泪膜破裂时间测定(BUT)，角膜荧光素染色检查(FL)，比较分析两组人员各项检查结果，分析CRF患者发生干眼的相关因素。

结果：CRF组患者的泪液分泌试验值，泪膜破裂时间低于正常人群(P<0.05)。CRF组泪液分泌减少(SⅠt<10mm/5min)的比例为49.2%(60/122)高于对照组10.0%(12/122)，两组比较差异有统计学意义(χ²=45.39，P<0.05)。CRF泪膜不稳定(BUT≤10s)的比例为75.4%(92/122)，高于对照组27.0%(33/122)，其差异有统计学意义(χ²=57.1，P<0.05)。角膜荧光染色(FL)阳性率为37.7%(46/122)，高于对照组10.7%(13/122)，两组差异有统计学意义(χ²=24.34，P<0.05)。

结论：慢性肾功能衰竭患者泪液分泌减少，泪膜稳定性下降是干眼症的易患人群，临床上应注意对CRF患者干眼的治疗。

METHODS: Sixty-one cases(122 eyes)of patients with CRF(CRF group)and 61 cases(122 eyes)of healthy persons(control group)were carried out on Schirmer Ⅰ test(SⅠt), break-up time of tear film(BUT), corneal fluorescein staining(FL), test results of two groups were compared and related factors of dry eye in CRF patients were analyzed.

RESULTS: The results of SⅠt and BUT in CRF group were lower than that in the control group(P<0.05). The proportion of tear secretion reduce in CRF group(SⅠt<10mm/5min)was 49.2%(60/122), which was higher than that in the control group(10.0%, 12/122), the difference was statistically significant(χ²=45.39, P<0.05). The percentage of instability of tear film in CRF group(BUT≤10s)was 75.4%(92/122), which was significantly higher than that in the control group(27.0%, 33/122)(χ²=57.1, P<0.05). The positive rate of corneal FL was 37.7%(46/122), which was higher than that of the control group(10.7%, 13/122), there was a statistically significant difference(χ²= 24.34, P<0.05).

CONCLUSION: CRF patients with a decrease in tear film stability and tear secretion are susceptible population to dry eye, clinically should be paid attention to the treatment.