方法：前瞻性研究。对我院2013-11/2014-06就诊的小梁切除术后合并干眼症的病例63例63眼，按就诊顺序，随机分为观察组和对照组，观察组采用人工泪液联合普拉洛芬点眼治疗，对照组采用人工泪液治疗。分别于治疗前、治疗后1，2，4wk，对症状、体征进行评分，并观察泪膜破裂时间(BUT)、泪液分泌试验(SⅠt)、荧光素染色(FL)，比较每组治疗前、后效果差异。

结果：用药第2wk后，观察组感觉性症状好转，评分差异有统计学意义(P<0.05)，两组的角膜荧光染色评分差异均有统计学意义(P<0.05)； 4wk后，两组感觉性症状及观察组眼表体征均有好转，评分差异有统计学意义(P<0.05)，观察组的泪膜破裂时间及两组的角膜荧光素染色评分差异均有统计学意义(P<0.05)。

结论：人工泪液联合普拉洛芬滴眼液治疗小梁切除术后合并轻中度干眼症效果良好。

METHODS: This prospective case control study included 63 cases(63 eyes)of patients with mild to moderate dry eye syndrome after trabbeculectomy in our hospital from November 2013 to June 2013. All subjects were randomly divided into two groups. Observation group was treated with combined pranoprofen eye drops and artificial tears and control group received simple artificial tears marking the eyes at 1, 2, 4wk. The patient's symptoms, signs, BUT, SⅠt, and FL were observed before treatment and 1, 2, 4wk after treatment.

RESULTS:After 2wk, the symptoms of observation group were improved, there was statistically significant difference(P<0.05). FL difference of each group was statistically significant(P<0.05); After 4wk, symptoms and signs were improved. There was statistically significant difference(P<0.05). The BUT of the observation group and corneal FL scores of two groups showed significant differences(P<0.05).

CONCLUSION: Artificial tears joint pranoprofen eye drops has good curative effect in the treatment of mild to moderate dry eye syndrome after trabbeculectomy.