[关键词]
[摘要]
脉络膜新生血管是湿性黄斑变性(neovascularage-related macular degeneration，nAMD)的主要发病机制，而血管内皮生长因子(vascular endothelial growth factor，VEGF)促进新生血管的作用已受到广泛认可，目前针对VEGF不同靶点的药物已广泛运用于治疗nAMD。胎盘生长因子(placental growth factor，PIGF)是抗VEGF的一个新靶点，与VEGF-A有协同作用，可促进新生血管，刺激内皮细胞迁移增殖，介导免疫炎症反应，且在已成熟血管上无表达，特异性较高。本文就PIGF在nAMD中的作用进行探讨。
[Key word]
[Abstract]
Choroidal neovascularization is the primary pathogenesis of neovascularage-related macular degeneration(nAMD), and the role of vascular endothelial growth factor(VEGF)in neovascularization has been widely recognized. Currently, drugs target different targets of VEGF have been widely used in the treatment of nAMD. As a subtype of VEGF, placental growth factor(PIGF)has synergistic effects with VEGF-A on promoting angiogenesis, stimulating the migration of endothelial cell proliferation and mediating immune inflammatory response. There is no expression of PIGF in mature blood vessels so PIGF hashigh specificity. In this paper, the role of PIGF in the pathogenesis and treatment of nAMD is reviewed.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81271026)
